Efficient and versatile synthesis of A-ring precursors of 1α,25-dihydroxyvitamin D3 and analogues. Application to the synthesis of Lythgoe-Roche phosphine oxide

DOI: 10.1016/S0040-4039(97)01005-8

Source and publish data:

Tetrahedron Letters p. 4713 - 4716 (1997)

Update date:2022-08-03

Topics:

Authors:

Mourino, Antonio

Torneiro, Mercedes

Vitale, Cristian

Fernandez, Sara

Perez-Sestelo, Jose

Anne, Sofia

Gregorio, Carlos

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0040-4039(97)01005-8

An efficient, versatile synthesis of Lythgoe-Phosphine Oxide has been developed starting from l-carvene. The key steps are rupture of protected epoxide 7 to give dicarbonyl compound 8, preparation of vinylic triflate 2, and palladium-catalysed cyclization-carbonylation of vinylic triflate 2.

Full text of DOI:10.1016/S0040-4039(97)01005-8

Products guided by the article

Product name:E-(3S,5R)-[3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylenecyclohexylidene]acetic acid methyl ester

Cas No:141847-50-9

R&D Labs maybe for 141847-50-9

SHANDONG CREDAGRI CHEMICAL CO., LTD.

Contact:+86-531-88872050

Address:ROOM 601A, BUILDING 2, SHUNTAI SQUARE, NO. 2000 SHUNHUA ROAD, HI-TECH DEVELOPMENT ZONE, JINAN, CHINA.
Innua Petrochem Ltd.

Contact:+1-284-4950244

Address:Box 3069, Road Town, Tortola, British Virgin Islands
SuZhou Bichal Biological Technology CO.,LTD

Contact:+86-512-68051130

Address:NO.32 huoju road HI-TECH Industrial development zone SuZhou China
HANGZHOU TOYOND BIOTECH CO., LTD

Contact:+86-571-86965177

Address:No. 189, Fengqi East Road, Hangzhou, China
Chameleon Specialty Chemicals

Contact:+44 7958 511245

Address:PO Box 469, Manchester, UK

Relevant to this article

Design, synthesis and brain uptake of lat1-targeted amino acid prodrugs of dopamine

Doi:10.1007/s11095-012-0966-3
(2013)
A New Approach to the Synthesis of Antitumour Alkaloids with the Lycorane Skeleton

Doi:10.1016/S0040-4039(00)74224-9
(1992)
Asymmetric allylboration of aldehydes and ketones using 3,3′-disubstitutedbinaphthol-modified boronates

Doi:10.1021/ol0490882
(2004)
Photoactivated cell-killing involving a low molecular weight, donor-acceptor diphenylacetylene

Doi:10.1039/c9sc00199a
(2019)
Tetracyclic triterpenoids and terpenylated coumarins from the bark of Ailanthus altissima ( Tree of Heaven )

Doi:10.1016/j.phytochem.2012.10.008
(2013)
The first total synthesis of a 12-membered macrolide balticolid

Doi:10.1016/j.tetlet.2012.10.027
(2012)

Article Doi