141849-58-3

Upstream product

• 70156-57-9 2-Phenyl-3-oxo-1,4-thiazane 
• 2882-19-1 ethyl 2-phenyl-2-bromoacetate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 77082-31-6 2-phenylthiomorpholine 

Downstream Products

• 141849-61-8 N-(tert-Butoxycarbonyl)-2-phenyl-1,4-thiazane 1,1-dioxide 
• 141849-59-4 N-(tert-Butoxycarbonyl)-2-phenyl-1,4-thiazane 1-Oxide 

Relevant academic research and scientific papers

HETEROCYCLIC COMPOUNDS

Provided herein are compounds of formula (I) which comprise a thiomorpholine 1,1-dioxide or 1-imino-thiomorpholine 1-oxide moiety, or pharmaceutically acceptable salts of any of the foregoing, pharmaceutical compositions that include a compound described herein (including salts of the compound) and methods of synthesizing the same. Also provided are methods of treating Hepatitis B viral (HBV) infections using a compound of formula (I), or pharmaceutically acceptable salts thereof.

Synthesis of 2-Phenyl-, 3-Phenyl-, cis-2,3-Diphenyl-, and trans-2,3-Diphenyl-1,4-thiazanes and Derivatives (N-Methyl, N-Alkoxycarbonyl, S-Oxides, and S,S-Dioxides)

The syntheses of the title 1,4-thiazanes (thiamorpholines) by reduction of the 5-oxa-1,4-thiazanes resulting from the lactamization of the appropriate acyclic phenyl derivatives of 5-amino-3-thiapentanoic acid are reported.The oxidation reactions at sulfu