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Usage

Uses

Used in Pharmaceutical Industry:
2-Phenyl-thiomorpholine is used as a building block for the synthesis of various pharmaceuticals, contributing to the development of new drugs and therapeutic agents. Its unique structure allows it to be a valuable component in the creation of molecules with specific medicinal properties.
Used in Agrochemical Industry:
In the agrochemical industry, 2-Phenyl-thiomorpholine is utilized as a precursor in the synthesis of agrochemicals, such as pesticides and herbicides. Its ability to form carbon-sulfur bonds makes it a crucial element in the development of effective and targeted agrochemical products.
Used in Organic Chemistry:
2-Phenyl-thiomorpholine serves as a reagent in organic chemistry, particularly for the formation of carbon-sulfur bonds. This capability is essential in the synthesis of a wide range of organic compounds, expanding the scope of chemical reactions and products that can be achieved.
Used in Metal Ion Coordination Chemistry:
As a chelating agent, 2-Phenyl-thiomorpholine is used in metal ion coordination chemistry to form stable complexes with metal ions. This application is vital in various fields, including catalysis, material science, and environmental remediation, where the selective binding and manipulation of metal ions are required.
Used in Medicinal and Pharmaceutical Research:
Due to its potential biological activity, 2-Phenyl-thiomorpholine is studied for its possible use in medicinal and pharmaceutical fields. Researchers are exploring its properties to understand its potential as a therapeutic agent or as a component in the development of new drugs.

Upstream product

• 42109-49-9 2-phenylthiomorpholin-5-one 
• 37167-62-7 bromo-phenyl-acetic acid methyl ester 
• 2882-19-1 ethyl 2-phenyl-2-bromoacetate 
• 70156-57-9 2-Phenyl-3-oxo-1,4-thiazane 

Downstream Products

• 88789-01-9 N-Methyl-2-phenyl-1,4-thiazane 
• 141849-47-0 2-Phenyl-1,4-thiazane 1-Oxide 
• 141849-47-0 2-Phenyl-1,4-thiazane 1-Oxide 
• 141849-58-3 N-(tert-Butoxycarbonyl)-2-phenyl-1,4-thiazane 
• 141849-54-9 N-(Ethoxycarbonyl)-2-phenyl-1,4-thiazane 
• 141849-55-0 N-(Ethoxycarbonyl)-2-phenyl-1,4-thiazane 1-Oxide 
• 141849-55-0 N-(Ethoxycarbonyl)-2-phenyl-1,4-thiazane 1-Oxide 
• 141849-61-8 N-(tert-Butoxycarbonyl)-2-phenyl-1,4-thiazane 1,1-dioxide 
• 141849-59-4 N-(tert-Butoxycarbonyl)-2-phenyl-1,4-thiazane 1-Oxide 
• 83287-60-9 N-Methyl-2-phenyl-1,4-thiazane 1-Oxide 

Relevant academic research and scientific papers

HETEROCYCLIC COMPOUNDS

Provided herein are compounds of formula (I) which comprise a thiomorpholine 1,1-dioxide or 1-imino-thiomorpholine 1-oxide moiety, or pharmaceutically acceptable salts of any of the foregoing, pharmaceutical compositions that include a compound described herein (including salts of the compound) and methods of synthesizing the same. Also provided are methods of treating Hepatitis B viral (HBV) infections using a compound of formula (I), or pharmaceutically acceptable salts thereof.

Thiomorpholine Derivatives with Hypolipidemic and Antioxidant Activity

A number of thiomorpholine derivatives that are structurally similar to some substituted morpholines possessing antioxidant and hypocholesterolemic activity were synthesized. The new compounds incorporate an antioxidant moiety as the thiomorpholine N-subs

2-Arylthiomorpholine derivatives as potent and selective monoamine oxidase B inhibitors

2-Arylthiomorpholine and 2-arylthiomorpholin-5-one derivatives, designed as rigid and/or non-basic phenylethylamine analogues, were evaluated as rat and human monoamine oxidase inhibitors. Molecular docking provided insight into the binding mode of these inhibitors and rationalized their different potencies. Making the phenylethylamine scaffold rigid by fixing the amine chain in an extended six-membered ring conformation increased MAO-B (but not MAO-A) inhibitory activity relative to the more flexible α-methylated derivative. The presence of a basic nitrogen atom is not a prerequisite in either MAO-A or MAO-B. The best Ki values were in the 10-8 M range, with selectivities towards human MAO-B exceeding 2000-fold.

Synthesis of 2-Phenyl-, 3-Phenyl-, cis-2,3-Diphenyl-, and trans-2,3-Diphenyl-1,4-thiazanes and Derivatives (N-Methyl, N-Alkoxycarbonyl, S-Oxides, and S,S-Dioxides)

The syntheses of the title 1,4-thiazanes (thiamorpholines) by reduction of the 5-oxa-1,4-thiazanes resulting from the lactamization of the appropriate acyclic phenyl derivatives of 5-amino-3-thiapentanoic acid are reported.The oxidation reactions at sulfu