1419101-54-4

Basic information

• Product Name: 6-Boc-2-hydroxy-6-azaspiro[3.5]nonane
• Synonyms: 6-Boc-2-hydroxy-6-azaspiro[3.5]nonane;tert-butyl 2-hydroxy-6-azaspiro[3.5]nonane-6-carboxylate;6-Boc-2-hydroxy-6-azaspiro[3.5]nonane - H12087
• CAS NO: 1419101-54-4
• Molecular Formula: C₁₃H₂₃NO₃
• Molecular Weight: 241.32662
• Mol File: 1419101-54-4.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 350.7±35.0 °C(Predicted)
• Appearance: /
• Density: 1.12±0.1 g/cm3(Predicted)
• PKA: 14.97±0.20(Predicted)
• CAS DataBase Reference: 6-Boc-2-hydroxy-6-azaspiro[3.5]nonane(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Boc-2-hydroxy-6-azaspiro[3.5]nonane(1419101-54-4)
• EPA Substance Registry System: 6-Boc-2-hydroxy-6-azaspiro[3.5]nonane(1419101-54-4)

Safety Data

• Hazardous Substances Data: 1419101-54-4(Hazardous Substances Data)

Upstream product

• 276872-89-0 tert-butyl 3-methylidenepiperidine-1-carboxylate 
• 1359704-84-9 tert-butyl 2-oxo-6-azaspiro[3.5]nonane-6-carboxylate 
• 1359703-25-5 C₈H₁₃NO 
• 1359705-27-3 benzyl 2-oxo-6-azaspiro[3.5]nonane-6-carboxylate 
• 138163-15-2 3-methylenepiperidine-1-carboxylic acid benzyl ester 

Relevant articles and documents

Stereoselective Diboration of Spirocyclobutenes: A Platform for the Synthesis of Spirocycles with Orthogonal Exit Vectors

The diastereo- and enantioselective diboration of spirocyclobutenes provides a platform for the rapid preparation of a wide variety of chiral spirocyclic building blocks. The chemoselective functionalization of the carbon-boron bond in the products, including a stereospecific sp3-sp2 Suzuki–Miyaura cross-coupling reaction, provides a powerful tool to control the directionality and the nature of the exit vectors in the spirocyclic framework.

PYRAZOLE COMPOUNDS AS BTK INHIBITORS

The present invention encompasses compounds of the formula (I) wherein the groups R1, Cy, and Y are defined herein, which are suitable for the treatment of diseases related to BTK, process of making, pharmaceutical preparations which contain compounds and their methods of use.