141928-29-2

Upstream product

• 14371-10-9 (E)-3-phenylpropenal 
• 105-45-3 acetoacetic acid methyl ester 

Downstream Products

• 122046-62-2 (S)-goniothalamin 
• 57012-11-0 (E)-6-styryldihydro-2H-pyran-2,4(3H)-dione 
• 500-64-1 kawain 
• 111136-40-4 methyl (3R,5S,E)-3,5-dihydroxy-7-phenylhept-6-enoate 
• 121786-82-1 (E)-methyl erythro-3,5-dihydroxy-7-phenyl-hept-6-enoate 
• 107400-61-3 (3R^*,5R^*)-Methyl 3,5-Dihydroxy-7-phenylheptanoate 
• 103338-09-6 methyl (E,3S^*,5R^*)-3,5-dihydroxy-7-phenyl-6-heptenoate 
• 103338-09-6 methyl (+/-)-(3R*,5R*,6E)-3,5-dihydroxy-7-phenyl-6-heptanoate 
• 70670-14-3 (4S,6R,E)-4-hydroxy-6-(2-phenylethenyl)-tetrahydropyran-2-one 
• 70633-86-2 (4R,6R,1'E)-4-hydroxy-6-(2'-phenylvinyl)-3,4,5,6-tetrahydro-2H-pyran-2-one 

Relevant academic research and scientific papers

Characterisation of the broadly-specific O-methyl-transferase jerf from the late stages of jerangolid biosynthesis

We describe the characterisation of the O-methyltransferase JerF from the late stages of jerangolid biosynthesis. JerF is the first known example of an enzyme that catalyses the formation of a non-aromatic, cyclic methylenolether. The enzyme was overexpressed in E. coli and the cell-free extracts were used in bioconversion experiments. Chemical synthesis gave access to a series of substrate surrogates that covered a broad structural space. Enzymatic assays revealed a broad substrate tolerance and high regioselectivity of JerF, which makes it an attractive candidate for an application in chemoenzymatic synthesis with particular usefulness for late stage application on 4-methoxy-5,6-dihydro-2H-pyran-2-one-containing natural products.

Process for the preparation of derivatives of 3,5-dihydroxypentanoic acid

This invention is directed to a method for stereoselectively preparing a syn-dihydroxylated compound comprising reacting a 3-hydroxyket-1-one with a borohydride in the presence of titanium derivative.

Enzymes in Organic Synthesis, 11.- Enantioselective Lactonization of Methyl 3,5-Dihydroxyalkanoates. - An Access to (3R,5S,6E)-3-Hydroxy-7-phenyl-6-hepten-5-olide by Enzyme-Catalyzed Kinetic Resolution in Organic Solvents

By enzyme-catalyzed intramolecular transesterfication methyl (+/-)-(3R*,5S*,6E)-3,5-dihydroxy-7-phenyl-6-heptenoate (rac-4) can be enantioselectively converted into the δ-lactone 5.An enantiomeric excess of 80percent was obtained by