141987-52-2

Upstream product

• 108-05-4 vinyl acetate 
• 25772-85-4 (+/-)-1-chloro-3-(4-methoxyphenyloxy)-2-propanol 
• 108-22-5 Isopropenyl acetate 
• 2211-94-1 2,3-epoxypropyl p-methoxyphenyl ether 
• 150-76-5 4-methoxy-phenol 

Downstream Products

• 2211-94-1 4-methoxybenzyloxy ester of (S)-glycidol 

Relevant academic research and scientific papers

A facile and convenient chemoenzymatic synthesis of optically active O-(4-methoxyphenyl)-glycidol and 1,2-diacyl-sn-glycerol

A convenient preparation of the (R)- and (S)-enantiomers of O-(4-methoxyphenyl)-glycidol by a one-pot reduction of ketone 3 and in situ lipase mediated resolution is described. Activated moist aluminium oxide in the presence of Pseudomonas cepacia lipase immobilized on ceramic particles (PS-C) has been found effective for the transesterification leading to a high degree of enantioselectivity. These chiral glycidols were further used as a chiral precursor for the synthesis of biologically important 1,2-O-diacyl-sn-glycerol under mild reaction conditions. The present method is facile for the synthesis of chiral glycidols in high enantioselectivity when compared to the previously reported methods.

The efficient resolution of protected diols and hydroxy aldehydes by lipases: Steric auxilliary approach and synthetic applications

1,n-Diols (n = 2-5) and 2-hydroxy aldehydes protected with a steric auxilliary are transformed by Pseudomonas lipases with high enantioselectivity, thus allowing the efficient resolution of these molecules and the synthesis of related derivatives with high optical purity.

RESOLUTION OF RACEMIC O-(4-METHOXYPHENYL)GLYCIDOL

Racemic O-(4-methoxyphenyl)glycidol has been resolved in three steps by employing lipase mediated kinetic acylation of the halohydrin intermediates.

Enzyme Assisted Preparation of Enantiomerically Pure β-Adrenergic Blockers III. Optically Active Chlorohydrin Derivatives and Their Conversion

Optical active chlorohydrin derivatives 2a-m and 3a-m of both enantiomeric series were prepared via both enzymatic hydrolyses and acyltransfer reactions catalysed by a highly selective lipase from Pseudomonas sp..The resulting building blocks were further transformed into the corresponding β-blockers of high enantiomeric purity.