141996-76-1

Upstream product

• 108-59-8 malonic acid dimethyl ester 
• 141996-73-8 2-[3-((R)-2-Benzyloxycarbonylamino-3-phenyl-propionylamino)-2-oxo-propyl]-malonic acid dimethyl ester 

Downstream Products

• 141996-71-6 4-benzyl-7-methoxycarbonyl-4-methyl-3,6-dioxoperhydropyrrolo<1,2-a>pyrazine 
• 141996-78-3 (4S,7R,8aR)-4,7-dibenzyl-7-methoxycarbonyl-3,6-dioxoperhydropyrrolo<1,2-a>pyrazine 
• 141996-77-2 7-benzyl-4-methyl-7-methoxycarbonyl-3,6-dioxoperhydropyrrolo<1,2-a>pyrazine 

Relevant academic research and scientific papers

3,6-Dioxoperhydropyrrolo[1,2-a]pyrazines. A new approach to conformationally restricted tripeptides

Catalytic hydrogenation of the 4-ketodiesters, obtained from Z-Xaa-Gly (Xaa = Ala, Phe) halomethyl ketones and dimethyl malonate, provides readily access to the corresponding 4-substituted-3,6-dioxoperhydropyrrolo[1,2-a]pyrazine-7-carboxylic acid derivati