141996-77-2

Upstream product

• 141996-73-8 2-[3-((R)-2-Benzyloxycarbonylamino-3-phenyl-propionylamino)-2-oxo-propyl]-malonic acid dimethyl ester 
• 141996-72-7 2-[3-((R)-2-Benzyloxycarbonylamino-propionylamino)-2-oxo-propyl]-malonic acid dimethyl ester 
• 141996-76-1 2-((2R,6S)-6-Benzyl-5-oxo-piperazin-2-ylmethyl)-malonic acid dimethyl ester 
• 100-39-0 benzyl bromide 
• 141996-74-9 (4S,7R,8aR)-7-methoxycarbonyl-4-methyl-3,6-dioxoperhydropyrrolo<1,2-a>pyrazine 
• 142037-80-7 (4S,7R,8aS)-4-Methyl-3,6-dioxo-octahydro-pyrrolo[1,2-a]pyrazine-7-carboxylic acid methyl ester 

Relevant academic research and scientific papers

3,6-Dioxoperhydropyrrolo[1,2-a]pyrazines as templates for peptidomimetics

The synthesis of 4,7-di- and 4,7,7-trisubstituted 3,6-dioxoperhydropyrrolo[1,2-a]pyrazine-7-carboxylate derivatives is described. The approach used for the preparation of this heterocyclic template is based on the reductive amination of 4-ketodiesters derived from dipeptides.

3,6-Dioxoperhydropyrrolo[1,2-a]pyrazines. A new approach to conformationally restricted tripeptides

Catalytic hydrogenation of the 4-ketodiesters, obtained from Z-Xaa-Gly (Xaa = Ala, Phe) halomethyl ketones and dimethyl malonate, provides readily access to the corresponding 4-substituted-3,6-dioxoperhydropyrrolo[1,2-a]pyrazine-7-carboxylic acid derivati