142004-15-7

Basic information

• Product Name: diclazuril
• CAS NO: 142004-15-7
• Molecular Weight: 407.643
• Mol File: 142004-15-7.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: diclazuril(CAS DataBase Reference)
• NIST Chemistry Reference: diclazuril(142004-15-7)
• EPA Substance Registry System: diclazuril(142004-15-7)

Safety Data

• Hazardous Substances Data: 142004-15-7(Hazardous Substances Data)

Upstream product

• 132252-58-5 2,6-dichloro-alpha-(4-chlorophenyl)-4-aminobenzeneacetonitrile 
• 298-12-4 Glyoxilic acid 
• 103317-59-5 2-(4'-chlorophenyl)-2-(2,6-dichloro-4-nitrophenyl)acetonitrile 
• 7279-45-0 dichloroacetyl-carbamic acid ethyl ester 
• 99-30-9 4-nitro-2,6-dichloroaniline 
• 20098-48-0 3,4,5-trichloronitrobenzen 

Downstream Products

• 112206-59-4 2,6-dichloro-α-(4-chlorophenyl)-4-(4,5-dihydro-3,5-dioxo-1,2,4-triazin-2(3H)-yl)benzeneethanethioamide 
• 1606159-95-8 2-(4-chlorophenyl)-2-(2,6-dichloro-4-(4-(3-methylbut-2-enyl)-3,5-dioxo-4,5-dihydro-1,2,4-triazin-2(3H)-yl)phenyl)acetonitrile 

Relevant articles and documents

Preparation method of triazinone ring

A preparation method of a triazinone ring relates to the technical field of veterinary drugs, and comprises the following steps: carrying out a diazo condensation reaction on a condensation compound aniline and potassium ethyl malonate, carrying out an amidation reaction with sodium cyanate under an acidic condition, adding acetic acid and sodium acetate, heating, heating, and carrying out a cyclization reaction to obtain a triazinone compound. According to the method, operations such as filtration and separation are not needed before the finished product is obtained, the product loss is reduced, the method has the advantages of simple process and high yield, the yield of the salmizuril can reach 89.65%-94.81%, and the yield of the diclazuril can reach 80.20%-94.11%; and the problem of odor generation of decarboxylation reaction in the production process is also solved, and the method is beneficial to environmental protection and suitable for industrial production.

A coccidian preparation method

The invention relates to a preparation method for diclazuril. A document reports that the synthesis of diclazuril is carried out in a such way that 2,6-dichloro-para-nitroaniline or 3,4,5-trichloronitrobenzene is used as an initial raw material and is subjected to diazotization reaction, substitution reaction, reduction reaction and the like to prepare a common intermediate 3. The existing process has many steps and is low in overall yield so that the costs of diclazuril raw materials and preparation stay at a high level. The invention provides a synthetic process of diclazuril. Particularly, the synthetic process comprises the steps that an intermediate 4 is prepared by performing reaction on the intermediate 3 and sodium nitrite by means of reduction and is subjected to cyclization and ring enlargement to obtain a product. In the route, a column chromatography means is not adopted; therefore, the process is short in the reaction steps and is suitable for industrial production.

1, 2, 4-Triazin-3-one derivatives, production and use thereof

The present invention provides a novel triazine derivative of the formula STR1 wherein ring A is an optionally substituted aromatic group; X is an oxygen or sulfur atom; R1 and R6 are each a hydrogen atom or an optionally substituted hydrocarbon residue or heterocyclic group which may bound through a hetero-atom; R2 and R3 are each independently a hydrogen atom, a halogen atom, or a group bound through a carbon, oxygen or sulfur atom, or taken together, represent =S; R4 and R5 are each independently a hydrogen atom, a halogen-atom, or a group bound through a carbon, oxygen, nitrogen or sulfur atom; R1 and R2, and R5 and R6 may each bind together to form a chemical bond; provided that where ring A is a phenyl group having at least a halogen atom in position -2 or 4 and X is an oxygen atom, R4 and R5 do not conjoin to form a chemical bond, or a salt thereof. The invention also encompasses an antiprotozoan composition comprising the novel triazine derivative or a salt thereof.