132252-58-5Relevant articles and documents
Preparation method of anticoccidial drug Diclazuril
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, (2018/04/03)
The invention discloses a preparation method of an anticoccidial drug Diclazuril. The method takes 3,4,5-trichloronitrobenzene as a raw material and the 3,4,5-trichloronitrobenzene and 4-chlorobenzylcyanide are subjected to condensation reaction to generate 2,6-dichloro-alpha-(4-chlorobenzyl)-4-nitrophenylacetonitrile; enabling a condensate and hydrazine hydrate to be subjected to reduction to generate 2,6-dichloro-alpha-(4-chlorobenzyl)-4-aminophenylacetonitrile, enabling a reduzate and malonyl ethyl dicarbamate to be subjected to diazo, coupling, cyclization, hydrolysis and decarboxylationone-pot reaction to generate the Diclazuril. The method disclosed by the invention has a simple technology and is easy to operate; the environment protection problem caused by the fact that the odor of thioglycolic acid is great in a decarboxylation process of the Diclazuril is solved; meanwhile, the yield is improved and the total yield of the Diclazuril synthesized by taking 2,6-dichloro p-nitroaniline as the raw material is 43.8 percent, so that the preparation method is suitable for industrial production.
Diclazuril and isotope internal standard D4-Diclazuril method for the preparation of
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, (2016/10/07)
The invention relates to a preparation method for diclazuril and isotope interior label D4-diclazuril. In the invention, 2, 6-dichloro-4-nitroaniline is adopted as a raw material, and the raw material is subjected to a sandmeyer reaction, affinity substitution, reduction, diazotization, diazonium reduction, a two-step condensation reaction, cyclization and refining, so that the diclazuril or the isotope interior label D4-diclazuril competitive product is obtained. According to the invention, during the process, the affinity substitution and the nitro-reduction can be continuously implemented without processing, and the diazotization, the diazonium reduction as well as the two-step condensation reaction can realize one-pot synthesis, the material prepared is high in purity and can reach 99.5%, the total yield is increased by about 10% as compared with that of the prior art, and the blank of the detection field of the medicine is filled up.