142010-17-1

Upstream product

• 98447-30-4 2-bromo-4-methoxy-1-nitrobenzene 
• 292638-85-8 acrylic acid methyl ester 
• 16133-49-6 5-methoxy-2-nitroaniline 
• 20357-24-8 5-methoxy-2-nitro-benzaldehyde 
• 16695-14-0 Malonic acid monomethyl ester 
• 142010-16-0 2-Nitro-5-hydroxycinnamic acid 
• 77-78-1 dimethyl sulfate 
• 10226-40-1 5-methoxy-2-nitrocinnamic acid 

Downstream Products

• 54197-64-7 6-methoxy-2-oxo-1,2,3,4-tetrahydroquinoline 
• 142010-15-9 Cyclohexyl-carbamic acid 1,3-dimethyl-1,2,3,4,5,6-hexahydro-2,6-methano-benzo[d][1,3]diazocin-8-yl ester 
• 142010-19-3 3-[[2-[(methoxycarbonyl)ethenyl]-4-methoxyphenyl]amino]-3-oxopropanoic acid, ethyl ester 
• 125810-74-4 6-Methoxy-4-methoxycarbonylmethyl-2-oxo-1,2,3,4-tetrahydro-quinoline-3-carboxylic acid methyl ester 
• 125810-76-6 (6-Methoxy-1-methyl-2-oxo-1,2,3,4-tetrahydro-quinolin-4-yl)-acetic acid methyl ester 
• 125810-75-5 (6-Methoxy-2-oxo-1,2,3,4-tetrahydro-quinolin-4-yl)-acetic acid methyl ester 
• 231293-65-5 methyl [2-(4-chlorobenzoyl)-5-methoxy-1H-indol-3-yl]acetate 
• 231296-73-4 methyl trans-5-methoxy-2-[(phenylsulfonyl)amino]cinnamate 
• 142010-18-2 methyl (2E)-3-(2′-amino-5′-methoxyphenyl)prop-2-enoate 

Relevant academic research and scientific papers

Transition metal complexes in organic synthesis, part 36. Cyclization of tricarbonyliron complexes by oxygen to 4a,9a-Dihydro-9H-carbazoles: Application to the synthesis of mukonine, mukonidine, and pyrido[3,2,1-jk]carbazoles

Aryl-substituted tricarbonyl(η4-cyclohexa-1,3-diene)iron complexes are oxidatively cyclized in protic medium in the air to tricarbonyliron-complexed 4a,9a-dihydro-9H-carbazoles. The method is applied to the total synthesis of mukonine and mukon

Synthesis and evaluation of 2-carboxy indole derivatives as potent and selective anti-leukemic agents

Despite the success achieved in the treatment of acute lymphoblastic leukemia (ALL), the search for new drugs featuring selectivity against leukemia cells and effectiveness to prevent relapsed ALL is still highly desirable. Here, we described the synthesi

Multibond Forming Tandem Reactions of Anilines via Stable Aryl Diazonium Salts: One-Pot Synthesis of 3,4-Dihydroquinolin-2-ones

A fast and effective one-pot tandem process that generates Heck coupled products from readily available anilines via stable aryl diazonium tosylate salts was developed. The mild and simple procedure involves rapid formation of aryl diazonium salts using a polymer-supported nitrite reagent and p-tosic acid, followed by a base-free Heck-Matsuda coupling with acrylates and styrenes. Using 2-nitroanilines as substrates, the one-pot tandem process was extended for the direct synthesis of 3,4-dihydroquinolin-2-ones. In this case, following diazotization and Heck-Matsuda coupling to give methyl cinnamates, addition of hydrogen and reutilization of the palladium catalyst for reduction of the nitro group and hydrogenation of the alkene resulted in efficient formation of 3,4-dihydroquinolin-2-ones. The synthetic utility of this one-pot, four-stage process was demonstrated with the five-pot synthesis of a quinolinone-based sodium ion channel modulator.

Reductive cyclizations of nitroarenes to hydroxamic acids by visible light photoredox catalysis

We have developed a photocatalytic reduction of nitroarenes as an efficient, chemoselective route to biologically important N-phenyl hydroxamic acid scaffolds. Optimal conditions call for 2.5 mol% of a ruthenium photocatalyst, visible light irradiation, and a dihydropyridine terminal reductant. Because of the mild nature of the visible light activation, functional groups that might be sensitive to other non-photochemical reduction methods are easily tolerated. Georg Thieme Verlag Stuttgart New York.

2,3-substituted indole compounds as anti-inflammatory and analgesic agents

This invention provides a compound of the following formula: or the pharmaceutically acceptable salts thereof wherein Z is OH, C1-6 alkoxy, —NR2R3 or heterocycle; Q is selected from the following: (a) an optionally substituted phenyl, (b) an optionally substituted 6-membered monocyclic aromatic group containing one, two, three or four nitrogen atom(s), (c) an optionally substituted 5-membered monocyclic aromatic group containing one heteroatom selected from O, S and N and optionally containing one, two or three nitrogen atom(s) in addition to said heteroatom, (d) an optionally substituted C3-7 cycloalkyl and (e) an optionally substituted benzo-fuzed heterocycle; R1 is hydrogen, C1-4 alkyl or halo; R2 and R3 are independently hydrogen, OH, C1-4 alkoxy, C1-4 alkyl or C1-4 alkyl substituted with halo, OH, C1-4 alkoxy or CN; X is independently selected from H, halo, C1-4 alkyl, halo-substituted C1-4 alkyl, OH, C1-4 alkoxy, halo-substituted C1-4 alkoxy, C1-4 alkylthio, NO2, NH2, di-(C1-4 alkyl)amino and CN; and n is 0, 1, 2, 3 and 4.This invention also provides a pharmaceutical composition useful for the treatment of a medical condition in which prostaglandins are implicated as pathogens.

Bicycliccarbonyl indole compounds as anti-inflammatory/analgesic agents

This invention provides a compound of the following formula: or the pharmaceutically acceptable salts thereof wherein A is C1-6alkylene or —NR1—; Z is C(═L)R2, or SO2R3; U is CH or N; W and Y are inde

SYNTHESIS AND CARBAMOYLATION OF 1,2,3,4,5,6-HEXAHYDRO-1,3-DIMETHYL-2,6-METHANO-1,3-BENZODIAZOCIN-8-OL: BRIDGED ANALOGUES OF PHYSOSTIGMIN

The synthesis and carbamoylation of 2,6-methano-1,3-benzodiazocin-8-ol is described.A one pot silyl-aryl ether to carbamate transformation was developed.The compounds are analogues of the cholinesterase inhibitor physostigmin.