142016-30-6Relevant academic research and scientific papers
Lanthanide(III)-Catalyzed Synthesis of trans-Diaminocyclopentenones from Substituted Furfurals and Secondary Amines via a Domino Ring-Opening/4π-Electrocyclization Pathway
Hiscox, Afton,Ribeiro, Kauan,Batey, Robert A.
supporting information, p. 6668 - 6672 (2018/10/24)
A strategy toward the synthesis of trans-4,5-diaminocyclopent-2-enones is described. This core motif is embedded in the marine sponge derived alkaloids agelamadin B and nagelamide J. A variety of 2-substituted trans-4,5-diaminocyclopent-2-enones were synthesized in good to quantitative yields using lanthanide(III) catalysis. The products were formed exclusively as the trans-diastereomers via a mechanism in which the C4-C5 bond formation occurs through a 4π-conrotatory electrocyclization. The precursor 3-substituted furfurals can be readily accessed using palladium(0)-catalyzed cross-coupling between 3-bromofurfural and boronic acids, trifluoroborate salts, or alkynes.
Nickel-catalyzed cross-coupling of organogold reagents
Hirner, Joshua J.,Blum, Suzanne A.
scheme or table, p. 1299 - 1302 (2011/04/22)
Organogold compounds undergo nickel-catalyzed cross-coupling reactions with aryl and vinyl bromides in high yield under mild conditions. The reaction tolerates both electron-rich and electron-poor organogold complexes, and olefinic bromides undergo cross-coupling with high stereoselectivity. This novel transformation links well-established nickel catalysis with more recent developments in organogold transformations.
ANGIOTENSIN II ANTAGONIZING HETEROCYCLIC DERIVATIVES
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, (2008/06/13)
The invention relates to compounds of the formula STR1 wherein STR2 represents a condensed or uncondensed imidazolyl ring and the rest of the variables are as defined in the specification. They are angiotensin II antagonists useful for treating hypertension, etc..
