1420205-82-8Relevant articles and documents
Design and synthesis of a novel series of cyanoindole derivatives as potent γ-secretase modulators
Bischoff, Fran?ois P.,Velter, Adriana Ingrid,Minne, Garrett,Pieters, Serge,Berthelot, Didier,De Cleyn, Michel,Gijsen, Harrie J.M.,Macdonald, Gregor,Surkyn, Michel,Van Brandt, Sven,Van Roosbroeck, Yves,Zavattaro, Chiara,Mercken, Marc,Austin, Nigel,Dhuyvetter, Deborah,Borghys, Herman,Ahmad, Ishtiyaque,Samanta, Swapan Kumar
supporting information, p. 1737 - 1745 (2019/05/22)
The discovery, design and synthesis of a new series of GSMs is described. The classical imidazole heterocycle has been replaced by a cyano group attached to an indole nucleus. The exploration of this series has led to compound 26-S which combined high in