142037-06-7

Basic information

• Product Name: 2-Propanol, 1-chloro-3-(4-methoxyphenoxy)-, (R)-
• CAS NO: 142037-06-7
• Molecular Formula: C10H13ClO3
• Molecular Weight: 216.664
• Mol File: 142037-06-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-Propanol, 1-chloro-3-(4-methoxyphenoxy)-, (R)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propanol, 1-chloro-3-(4-methoxyphenoxy)-, (R)-(142037-06-7)
• EPA Substance Registry System: 2-Propanol, 1-chloro-3-(4-methoxyphenoxy)-, (R)-(142037-06-7)

Safety Data

• Hazardous Substances Data: 142037-06-7(Hazardous Substances Data)

Upstream product

• 108-22-5 Isopropenyl acetate 
• 25772-85-4 (+/-)-1-chloro-3-(4-methoxyphenyloxy)-2-propanol 
• 150-76-5 4-methoxy-phenol 
• 142036-87-1 Acetic acid 1-chloromethyl-2-(4-methoxy-phenoxy)-ethyl ester 
• 2211-94-1 2,3-epoxypropyl p-methoxyphenyl ether 

Downstream Products

• 17131-52-1 (S)-1-O-(4-methoxyphenyl)glycerol 
• 858345-18-3 2,3-di-O-palmitoyl-1-O-(4'-methoxyphenyl)-sn-glycerol 
• 2211-94-1 (2S)-2-{[4-(methoxy)phenoxy]methyl}oxirane 

Relevant articles and documents

A facile and convenient chemoenzymatic synthesis of optically active O-(4-methoxyphenyl)-glycidol and 1,2-diacyl-sn-glycerol

A convenient preparation of the (R)- and (S)-enantiomers of O-(4-methoxyphenyl)-glycidol by a one-pot reduction of ketone 3 and in situ lipase mediated resolution is described. Activated moist aluminium oxide in the presence of Pseudomonas cepacia lipase immobilized on ceramic particles (PS-C) has been found effective for the transesterification leading to a high degree of enantioselectivity. These chiral glycidols were further used as a chiral precursor for the synthesis of biologically important 1,2-O-diacyl-sn-glycerol under mild reaction conditions. The present method is facile for the synthesis of chiral glycidols in high enantioselectivity when compared to the previously reported methods.

RESOLUTION OF RACEMIC O-(4-METHOXYPHENYL)GLYCIDOL

Racemic O-(4-methoxyphenyl)glycidol has been resolved in three steps by employing lipase mediated kinetic acylation of the halohydrin intermediates.