142037-19-2

Upstream product

• 141987-54-4 1-Phenyl-3-chlor-propyl-monochloracetat 
• 936-59-4 3-chloropropiophenone 
• 18776-12-0 3-chloro-1-phenyl-propan-1-ol 

Downstream Products

• 112066-67-8 (R)-N-methyl-3-(2-methoxyphenoxy)-3-phenyl-1-propanamine 
• 112066-66-7 (S)-N-methyl-3-(2-methoxyphenoxy)-3-phenyl-1-propanamine 
• 114446-49-0 -(+)-1-chloro-3-phenyl-3-(2-methoxyphenoxy)propane 
• 105314-53-2 (S)-N-methyl-3-(2-methylphenoxy)-3-phenyl-1-propanamine 
• 114446-47-8 -(-)-1-chloro-3-phenyl-3-(2-methylphenoxy)propane 
• 114446-48-9 -(+)-1-chloro-3-phenyl-3-<4-(trifluoromethyl)phenoxy>propane 
• 100568-02-3 (S)-fluoxetine 
• 54910-89-3 (R)-fluoxetine 
• 105314-52-1 (R)-tomoxetine 
• 114133-37-8 (S)-N-methyl-3-amino-1-phenyl-1-propanol 
• 114247-06-2 (S)-fluoxetine hydrochloride 
• 100306-34-1 3-chloro-1-phenylpropanol 

Relevant academic research and scientific papers

Hydrolases in organic synthesis: Preparation of enantiomerically pure compounds

Esterhydrolases (Esterases, Lipases) are highly (chemo-, regio- and enantio-) selective biocatalysts for the transformation of racemic and achiral substrates into enantiomerically pure compounds.Numerous examples for their application in the preparation of synthetically useful chiral auxiliaries and building blocks for flavour compounds, pheromones and several pharmaceuticals including β-adrenergic blockers, antidepressants and ACE inhibitors are presented.

An efficient route to enantiomerically pure antidepressants: Tomoxetine, nisoxetine and fluoxetine

Both enantiomers (R)- and (S)-3-chloro-1-phenyl-1-propanol can be obtained conveniently by an efficient enzymatic resolution process. They can be converted via enantioconvergent routes into all enantiomers of the important antidepressants (R)- and (S)-Tomoxetine, Fluoxetine and Nisoxetine.