114247-06-2 Usage
Description
S-(+)-FLUOXETINE HYDROCHLORIDE, also known as fluoxetine hydrochloride or fluoxetine HCl, is a psychotropic agent and a member of the selective serotonin reuptake inhibitor (SSRI) class of antidepressant drugs. It is the active ingredient in the medication Prozac. This white solid is formed by the reaction of (S)-fluoxetine with one equivalent of hydrochloric acid and is used for its effects on modulating serotonin levels in the brain.
Uses
Used in Pharmaceutical Industry:
S-(+)-FLUOXETINE HYDROCHLORIDE is used as an antidepressant for treating various forms of depression and related disorders. It works by selectively inhibiting the reuptake of serotonin in the brain, thereby increasing the availability of serotonin and helping to alleviate symptoms of depression.
Used in Mental Health Treatment:
S-(+)-FLUOXETINE HYDROCHLORIDE is used as a psychotropic agent for managing mental health conditions such as obsessive-compulsive disorder (OCD), bulimia nervosa, and panic disorder. Its ability to modulate serotonin levels in the brain makes it an effective treatment option for these conditions.
Used in Veterinary Medicine:
S-(+)-FLUOXETINE HYDROCHLORIDE is also used as a veterinary drug for treating behavioral and mood disorders in animals, such as separation anxiety and obsessive-compulsive behaviors in dogs and cats. Its application in veterinary medicine helps improve the quality of life for pets suffering from these conditions.
Biochem/physiol Actions
Fluoxetine hcl (hydrochloride) is a selective serotonin reuptake inhibitor and functions as an antidepressant. This drug works at presynaptic terminals where it prevents the reuptake of serotonin, resulting in the accumulation of serotonin in extracellular fluid at synapses.
Check Digit Verification of cas no
The CAS Registry Mumber 114247-06-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,4,2,4 and 7 respectively; the second part has 2 digits, 0 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 114247-06:
(8*1)+(7*1)+(6*4)+(5*2)+(4*4)+(3*7)+(2*0)+(1*6)=92
92 % 10 = 2
So 114247-06-2 is a valid CAS Registry Number.
InChI:InChI=1/C17H18F3NO.ClH/c1-21-12-11-16(13-5-3-2-4-6-13)22-15-9-7-14(8-10-15)17(18,19)20;/h2-10,16,21H,11-12H2,1H3;1H/t16-;/m0./s1
114247-06-2Relevant articles and documents
Preparation of polymer-supported Ru-TsDPEN catalysts and use for enantioselective synthesis of (S)-fluoxetine
Li, Yangzhou,Li, Zhiming,Li, Feng,Wang, Quanrui,Tao, Fanggang
, p. 2513 - 2518 (2007/10/03)
Polymer-supported chiral ligands 9 and 17 were prepared based on Noyori's (1S,2S)- or (1R,2R)-N-(p-tolylsulfonyl)-1,2-diphenylethylenediamine. The combination with [RuCl2(p-cymene)]2 has been shown to exhibit high activities and enantioselectivities for heterogeneous asymmetric transfer hydrogenation of aromatic ketones (19a-c) with formic acid-triethylamine azeotrope as the hydrogen donor, whereby affording the respective optically active alcohols 20a-c, the key precursors of chiral fluoxetine. As exemplified by ligand 17 for substrate 19c, the catalysts can be recovered and reused in three consecutive runs with no significant decline in enantioselectivity. The procedure avoids the plausible contamination of fluoxetine by the toxic transition metal species. The Royal Society of Chemistry 2005.
Pd-catalyzed kinetic resolution of benzylic alcohols: A practical synthesis of (R)-tomoxetine and (S)-fluoxetine hydrochlorides
Ali, Iliyas Sayyed,Sudalai, Arumugam
, p. 5435 - 5436 (2007/10/03)
A convenient synthetic route to (R)-tomoxetine hydrochloride (90% ee) and (S)-fluoxetine hydrochloride (84% ee) is described. (S)-3-Phenyl-3-hydroxypropyl p-toluenesulphonate, the key intermediate, is obtained by the oxidative kinetic resolution of the corresponding racemic 3-phenyl-3-hydroxypropyl p-toluenesulphonate using (-)-sparteine/Pd(II)/O2 (1 atm) catalytic system.
Methods for treating depression and other disorders using optically pure R (-) fluoxetine and monoamine oxidase inhibitor
-
, (2008/06/13)
A method and composition are utilizing the pure R(-) isomer of fluoxetine which is a potent antidepressant and appetite suppressant substantially free of adverse effects. In addition, a method and composition are disclosed utilizing the pure R(-) isomer of fluoxetine which is useful to treat migraine headaches, pain, in particular chronic pain, psychoactive substance abuse disorders and obsessive compulsive disorders.
