142072-08-0

Basic information

• Product Name: Phosphoric acid, 3-hydroxy-1-methylpropyl bis(phenylmethyl) ester
• CAS NO: 142072-08-0
• Molecular Formula: C18H23O5P
• Molecular Weight: 350.351
• Mol File: 142072-08-0.mol

Chemical Properties

• CAS DataBase Reference: Phosphoric acid, 3-hydroxy-1-methylpropyl bis(phenylmethyl) ester(CAS DataBase Reference)
• NIST Chemistry Reference: Phosphoric acid, 3-hydroxy-1-methylpropyl bis(phenylmethyl) ester(142072-08-0)
• EPA Substance Registry System: Phosphoric acid, 3-hydroxy-1-methylpropyl bis(phenylmethyl) ester(142072-08-0)

Safety Data

• Hazardous Substances Data: 142072-08-0(Hazardous Substances Data)

Upstream product

• 18826-95-4 1.3-butanediol 
• 990-91-0 dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate 
• 142072-02-4 Phosphoric acid dibenzyl ester 1-methyl-3-triethylsilanyloxy-propyl ester 

Relevant articles and documents

A Novel Deacylation Method using Grignard Reagent without affecting the Neighbouring Base-sensitive Functional Groups

Methyl and ethyl Grignard reagents are shown to cleave ester functions such as benzoate and acetate without affecting the neighbouring base-sensitive functional groups.

Selective phosphorylation of diols with a Lewis acid catalyst

We report a method for the Lewis acid catalyzed phosphorylation of diols with pyrophosphates. Titanium alkoxides were found to be effective catalysts in the selective mono-phosphorylation for a range of diols. Diols of varying chain lengths and substituents were screened, to study the factors that influence mono- versus di-phosphorylation. It was discovered that 2-alkyl-2-amino-1,3- propanediols can be selectively mono-phosphorylated in up to 97% isolated yield. This structural core is mono-phosphorylated in numerous immunomodulating compounds including the FDA-approved drug, FTY720.