1421037-09-3Relevant articles and documents
Targeting loop adenines in G-quadruplex by a selective oxirane
Doria, Filippo,Nadai, Matteo,Folini, Marco,Scalabrin, Matteo,Germani, Luca,Sattin, Giovanna,Mella, Mariella,Palumbo, Manlio,Zaffaroni, Nadia,Fabris, Daniele,Freccero, Mauro,Richter, Sara N.
, p. 78 - 81 (2013/02/25)
Caught in the oxirane: Naphthalene diimides conjugated to a quinone methide and an oxirane have been synthesized and investigated as selective DNA G-quadruplex alkylating agents. The oxirane derivative generates a stable adduct with a G-quadruplex and shows selective alkylation of the loop adenines, as illustrated.