1421044-84-9Relevant academic research and scientific papers
Coupling of amines, dialkyl acetylenedicarboxylates and formaldehyde promoted by [n-Bu4N][HSO4]: An efficient synthesis of highly functionalized dihydro-2-oxopyrroles and bis-dihydro-2-oxopyrroles
Sajadikhah, Seyed Sajad,Hazeri, Nourallah
, p. 737 - 748 (2014)
Tetrabutylammonium hydrogen sulfate [n-Bu4N][HSO4] is used as an efficient catalyst for the one-pot, multi-component synthesis of highly substituted dihydro-2-oxopyrroles and bis-dihydro-2-oxopyrroles by means of reaction between amines, dialkyl acetylenedicarboxylates and formaldehyde in methanol at ambient temperature. This homogeneous catalyst procedure includes some important aspects like the easy work-up, no need to column chromatography, simple and readily available precursors, relatively short reaction time, and high yields. Graphical abstract: [Figure not available: see fulltext.]
ZrCl4 as an efficient catalyst for one-pot four-component synthesis of polysubstituted dihydropyrrol-2-ones
Sajadikhah, Seyed Sajad,Maghsoodlou, Malek Taher,Hazeri, Nourallah,Mohamadian-Souri, Sajad
, p. 2805 - 2814 (2016/03/30)
An efficient synthesis of polysubstituted dihydropyrrol-2-one derivatives via one-pot four-component domino reaction of amines, dialkyl acetylenedicarboxylates and formaldehyde in the presence of zirconium tetrachloride (ZrCl4) is described. The presented methodology offers several advantages such as simplicity of operation, good to high yields, short reaction times, inexpensive and readily available starting material and catalyst. Furthermore, the products were obtained through simple filtering with no need for column chromatography. Graphical abstract: [Figure not available: See fulltext.]
A simple and efficient approach to one-pot synthesis of mono- and bis-N-aryl-3-aminodihydropyrrol-2-one-4-carboxylates catalyzed by InCl 3
Sajadikhah, Seyed Sajad,Maghsoodlou, Malek Taher,Hazeri, Nourallah
, p. 58 - 60 (2014/02/14)
An efficient and straightforward procedure has been developed for the synthesis of highly substituted mono- and bis-N-aryl-3-aminodihydropyrrol-2-one- 4-carboxylates via a one-pot, four-component domino reaction of amines, dialkyl acetylenedicarboxylates and formaldehyde in the presence of InCl3 (20 mol%) in MeOH at ambient temperature. The salient advantages of this method are mild reaction conditions, environmentally benign, high to excellent yields, shorter reaction times, easy operation and no column chromatographic separation.
