1421044-87-2Relevant academic research and scientific papers
ZrCl4 as an efficient catalyst for one-pot four-component synthesis of polysubstituted dihydropyrrol-2-ones
Sajadikhah, Seyed Sajad,Maghsoodlou, Malek Taher,Hazeri, Nourallah,Mohamadian-Souri, Sajad
, p. 2805 - 2814 (2016)
An efficient synthesis of polysubstituted dihydropyrrol-2-one derivatives via one-pot four-component domino reaction of amines, dialkyl acetylenedicarboxylates and formaldehyde in the presence of zirconium tetrachloride (ZrCl4) is described. The presented methodology offers several advantages such as simplicity of operation, good to high yields, short reaction times, inexpensive and readily available starting material and catalyst. Furthermore, the products were obtained through simple filtering with no need for column chromatography. Graphical abstract: [Figure not available: See fulltext.]
Synthesis of functionalized dihydro-2-oxypyrroles and tetrahydropyridines using 2,6-pyridinedicarboxylic acid as an efficient and mild organocatalyst
Khan, Md. Musawwer,Khan, Sarfaraz,Iqbal, Safia,Saigal,Yousuf, Raveed
supporting information, p. 7504 - 7512 (2016/09/09)
Simple and efficient protocols have been developed for the synthesis of diversely functionalized dihydro-2-oxypyrroles and tetrahydropyridines. One-pot four-component reaction of dialkyl acetylenedicarboxylates, amines and formaldehyde in the presence of 2,6-pyridinedicarboxylic acid in methanol at room temperature provides dihydro-2-oxypyrroles. The combination of β-ketoesters, aromatic aldehydes and amines yielded tetrahydropyridine derivatives under the same reaction conditions. The salient features of these methods are mild reaction conditions, reduced reaction time, moderate to high yields, applicability to a broad range of substrates and no tedious column chromatographic separation.
A simple and efficient approach to one-pot synthesis of mono- and bis-N-aryl-3-aminodihydropyrrol-2-one-4-carboxylates catalyzed by InCl 3
Sajadikhah, Seyed Sajad,Maghsoodlou, Malek Taher,Hazeri, Nourallah
, p. 58 - 60 (2014/02/14)
An efficient and straightforward procedure has been developed for the synthesis of highly substituted mono- and bis-N-aryl-3-aminodihydropyrrol-2-one- 4-carboxylates via a one-pot, four-component domino reaction of amines, dialkyl acetylenedicarboxylates and formaldehyde in the presence of InCl3 (20 mol%) in MeOH at ambient temperature. The salient advantages of this method are mild reaction conditions, environmentally benign, high to excellent yields, shorter reaction times, easy operation and no column chromatographic separation.
Coupling of amines, dialkyl acetylenedicarboxylates and formaldehyde promoted by [n-Bu4N][HSO4]: An efficient synthesis of highly functionalized dihydro-2-oxopyrroles and bis-dihydro-2-oxopyrroles
Sajadikhah, Seyed Sajad,Hazeri, Nourallah
, p. 737 - 748 (2014/02/14)
Tetrabutylammonium hydrogen sulfate [n-Bu4N][HSO4] is used as an efficient catalyst for the one-pot, multi-component synthesis of highly substituted dihydro-2-oxopyrroles and bis-dihydro-2-oxopyrroles by means of reaction between amines, dialkyl acetylenedicarboxylates and formaldehyde in methanol at ambient temperature. This homogeneous catalyst procedure includes some important aspects like the easy work-up, no need to column chromatography, simple and readily available precursors, relatively short reaction time, and high yields. Graphical abstract: [Figure not available: see fulltext.]
