Research on Chemical Intermediates p. 2805 - 2814 (2016)
Update date:2022-08-04
Topics:
Sajadikhah, Seyed Sajad
Maghsoodlou, Malek Taher
Hazeri, Nourallah
Mohamadian-Souri, Sajad
An efficient synthesis of polysubstituted dihydropyrrol-2-one derivatives via one-pot four-component domino reaction of amines, dialkyl acetylenedicarboxylates and formaldehyde in the presence of zirconium tetrachloride (ZrCl4) is described. The presented methodology offers several advantages such as simplicity of operation, good to high yields, short reaction times, inexpensive and readily available starting material and catalyst. Furthermore, the products were obtained through simple filtering with no need for column chromatography. Graphical abstract: [Figure not available: See fulltext.]
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