142121-94-6

Usage

Uses

Used in Pharmaceutical Research and Drug Development:
N-Boc-DL-3-FluoroPhenylglycine is used as a building block in the synthesis of peptide-based therapeutics for various medical applications. The presence of the 3-fluoro group on the phenyl ring may confer unique properties to the compound, influencing its biological activity and interactions within biological systems.
Used in Peptide Synthesis:
N-Boc-DL-3-FluoroPhenylglycine is used as a protected amino acid in peptide synthesis. The Boc group protects the amino group from unwanted reactions during the synthesis process, allowing for the controlled formation of peptide bonds and the assembly of complex peptide structures.
Used in Medicinal Chemistry:
N-Boc-DL-3-FluoroPhenylglycine can be used as a starting material or intermediate in the development of novel pharmaceutical compounds. Its unique structural features, including the 3-fluoro group and the protected amino group, may enable the design of new drugs with improved potency, selectivity, and pharmacokinetic properties.
Used in Biochemical Research:
N-Boc-DL-3-FluoroPhenylglycine may be employed in biochemical research to study the effects of structural modifications on the properties and functions of peptides and proteins. N-Boc-DL-3-FluoroPhenylglycine can be used to investigate the role of specific amino acid residues in protein folding, stability, and interactions with other biomolecules.

Upstream product

• 124-38-9 carbon dioxide 
• 153903-29-8 N-(tert-butyloxycarbonyl)-3-fluorobenzylamine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 7292-74-2 DL-2-(3-fluorophenyl)glycine 
• 501-00-8 3-fluorophenylacetonitrile 
• 1237534-69-8 N-(tert-butoxycarbonyl)-α-(phenylsulfonyl)-3-fluorobenzylamine 
• 4248-19-5 tert-butyl carbazate 
• 456-48-4 3-Fluorobenzaldehyde 

Downstream Products

• 1379513-71-9 (3R)-3-(2-(tert-butoxycarbonylamino)-2-(3-fluorophenyl)acetoxy)-1-(2-oxo-2-phenylethyl)-1-azoniabicyclo[2.2.2]octane bromide 
• 1379513-70-8 (R)-quinuclidin-3-yl 2-(tert-butoxycarbonylamino)-2-(3-fluorophenyl)acetate 

Relevant academic research and scientific papers

HETEROARYL DERIVATIVES

Compounds of formula (I) described herein are both phosphodiesterase 4 (PDE4) enzyme inhibitors and muscarinic M3 receptor antagonists and are useful for the prevention and/or treatment of diseases of the respiratory tract characterized by airway obstruction.

HETEROARYL DERIVATIVES FOR THE TREATMENT OF RESPIRATORY DISEASES

The invention relates to novel compounds of formula (I) which are both phosphodiesterase 4 (PDE4) enzyme inhibitors and muscarinic M3 receptor antagonists, methods of preparing such compounds, compositions containing them and therapeutic use thereof.

PHENYLETHYLPYRIDINE DERIVATIVES AS PDE4-INHIBITORS

The invention relates to novel compounds which are both inhibitors of the phosphodiesterase 4 (PDE4) enzyme and muscarinic M3 receptor antagonists, methods of preparing such compounds, compositions containing them and therapeutic use thereof.

NOVEL COMPOUNDS

Compounds of formula (I) defined herein are both inhibitors of the phosphodiesterase 4 (PDE4) enzyme and muscarinic M3 receptor antagonists and are useful for the prevention and/or treatment of a disease of the respiratory tract characterized by airway obstruction.

GLYCINE DERIVATIVES AND THEIR USE AS MUSCARINIC RECEPTOR ANTAGONISTS

The present invention relates to alkaloid aminoester derivatives acting as muscarinic receptor antagonists, processes for their preparation, compositions comprising them and therapeutic uses thereof.

GLYCINE DERIVATIVES AND MEDICINAL COMPOSITIONS THEREOF

Alkaloid aminoester derivatives according to formula (I) and (VI) act as muscarinic receptor antagonists.

One-pot synthesis of α-amino acids from imines through CO2 incorporation: An alternative method for strecker synthesis

Itas a gas: A novel one-pot process for the synthesis of α-amino acids from imine equivalents using CO2 gas as a carbon source has been developed. This reaction was made possible by the reagent combination of TMSSnBu3 and CsF (see scheme). Three successive reactions (imine formation, stannylation, and carboxylation) proceeded in the same flask under these conditions to give products in up to 79 % yield. Boc=tert-butoxycarbonyl, TMS=trimethylsilyl.

Highly selective tripeptide thrombin inhibitors

Tripeptide aldehydes such as Boc-D-Phe-Pro-Arg-H (5l) exhibit potent direct inhibition of thrombin. This distinction offers important insight for the design of more potent and selective serine protease inhibitors which may be useful pharmacological tools and hold promise for development of clinically useful agents. The structure-activity relationships (SAR) on a series of anticoagulant peptides with high selectivity for the enzyme thrombin are discussed. The SAR is centered on a series of di- and tripeptide arginine aldehydes based on the structure of 5l. The structural and conformational role of the amino acid residue in position 1 was investigated by substitution with conformationally restricted aromatic amino acids, aromatic acids, and a dipeptide isostere containing the ψ[CH2N] amide bond replacement. Many of these peptides demonstrate potent antithrombotic activity along with selectivity toward thrombin, determined by comparison of in vitro inhibitory effects on trypsin, plasmin, factor Xa, and tissue plasminogen activator. Compound 5f, D-1-Tiq-Pro-Arg-H · sulfate is highly active and the most selective tripeptide aldehyde inhibitor of thrombin reported to date.

Site selective substitution of carbamate and carbamoyl protected benzylamines

Methoxy and fluoro substituted benzylamines can be metalated optionally at the position adjacent to the nitrogen bearing side chain or adjacent to the hetero substituent as a function of the acyl type protective group.