1421840-49-4

Basic information

• Product Name: (R)-4-chloro-2-((R)-1-(4-methylphenylsulfonamido)ethyl)phenyl tert-butyl(phenyl)phosphinate
• Synonyms: (R)-4-chloro-2-((R)-1-(4-methylphenylsulfonamido)ethyl)phenyl tert-butyl(phenyl)phosphinate
• CAS NO: 1421840-49-4
• Molecular Weight: 506.002
• Mol File: 1421840-49-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (R)-4-chloro-2-((R)-1-(4-methylphenylsulfonamido)ethyl)phenyl tert-butyl(phenyl)phosphinate(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-4-chloro-2-((R)-1-(4-methylphenylsulfonamido)ethyl)phenyl tert-butyl(phenyl)phosphinate(1421840-49-4)
• EPA Substance Registry System: (R)-4-chloro-2-((R)-1-(4-methylphenylsulfonamido)ethyl)phenyl tert-butyl(phenyl)phosphinate(1421840-49-4)

Safety Data

• Hazardous Substances Data: 1421840-49-4(Hazardous Substances Data)

Upstream product

• 824-72-6 P,P-dichlorophenylphosphine oxide 
• 1421840-45-0 C₂₁H₁₉ClNO₄PS 
• 594-19-4 tert.-butyl lithium 
• 1421840-44-9 (R)-N-(1-(5-chloro-2-hydroxyphenyl)ethyl)-4-methylbenzenesulfonamide 
• 1421840-58-5 (R)-6-chloro-4-methyl-3,4-dihydro-2H-benzo[e][1,3]oxazin-2-one 
• 1228571-53-6 (R)-2-(1-aminoethyl)-4-chlorophenol 

Downstream Products

• 67253-73-0 (S)-P-(tert-butyl)-P-phenylphosphinic amide 
• 67253-72-9 (R)-(-)-P-t-butyl-P-phenyl-N-phosphoramidate 

Relevant articles and documents

Efficient asymmetric synthesis of P -chiral phosphine oxides via properly designed and activated benzoxazaphosphinine-2-oxide agents

A general, efficient, and highly diastereoselective method for the synthesis of structurally and sterically diverse P-chiral phosphine oxides was developed. The method relies on sequential nucleophilic substitution on the versatile chiral phosphinyl transfer agent 1,3,2-benzoxazaphosphinine-2-oxide, which features enhanced and differentiated P-N and P-O bond reactivity toward nucleophiles. The reactivities of both bonds are fine-tuned to allow cleavage to occur even with sterically hindered nucleophiles under mild conditions.