1421852-06-3Relevant academic research and scientific papers
Cu(ii)-catalyzed cyclization of α-diazo-β-oxoamides with amines leading to pyrrol-3(2H)-ones
Wang, Zikun,Bi, Xihe,Liao, Peiqiu,Liu, Xu,Dong, Dewen
supporting information, p. 1309 - 1311 (2013/03/14)
A novel Cu(ii)-catalyzed cyclization of α-diazo-β-oxoamides with amines has been developed, constituting a straightforward method to construct pyrrol-3(2H)-one rings. The intramolecular hydrogen bonding effect in α-diazo-β-oxoamides plays an essential role in this reaction. A plausible reaction mechanism involving divergent generation and subsequent [2 + 3] cyclization of ketene and α-diazoimine intermediates was proposed.
