22760-66-3

Upstream product

• 674-82-8 4-methyleneoxetan-2-one 
• 62-53-3 aniline 
• 102-01-2 N-phenylacetoacetamide 
• 149848-31-7 8-Azido-6-phenyl-[1,3]dioxolo[4,5-g]quinoline 
• 149848-26-0 4-azido-8-trifluoromethylquinoline 
• 149848-24-8 8-Azido-6-methyl-[1,3]dioxolo[4,5-g]quinoline 
• 149848-23-7 4-Azido-6-cyclohexyl-2-methyl-quinoline 
• 149848-16-8 4-Azido-6-cyclohexyl-quinoline 
• 149848-27-1 4-Azido-7-chloro-2-methyl-quinoline 
• 69063-03-2 4-azido-7-chloro-quinoline 
• 74227-77-3 4-azido-7-(trifluoromethyl)quinoline 
• 32113-04-5 4-azido-2-methylquinoline 
• 87742-62-9 (Z)-3-Hydroxy-but-2-enoic acid phenylamide 

Downstream Products

• 1352398-74-3 5-methyl-N-phenyl-1-(pyridin-2-yl)-1H-1,2,3-triazole-4-carboxamide 
• 1352398-73-2 5-methyl-N-phenyl-1-propyl-1H-1,2,3-triazole-4-carboxamide 
• 1384290-58-7 1-methoxy-5-methyl-N-phenyl-1H-1,2,3-triazole-4-carboxamide 
• 1384290-52-1 tert-butyl (2-(5-methyl-4-(phenylcarbamoyl)-1H-1,2,3-triazol-1-yl)ethyl)carbamate 
• 1384290-56-5 (R)-5-methyl-N-phenyl-1-(1-phenylethyl)-1H-1,2,3-triazole-4-carboxamide 
• 24691-92-7 5-methyl-N-phenyl-1H-1,2,3-triazole-4-carboxamide 
• 70292-11-4 5-methyl-1-(naphthalen-1-yl)-N-phenyl-1H-1,2,3-triazole-4-carboxamide 
• 890645-57-5 1-(2-methoxyphenyl)-5-methyl-N-phenyl-1H-1,2,3-triazole-4-carboxamide 
• 1384290-50-9 1-cyclohexyl-5-methyl-N-phenyl-1H-1,2,3-triazole-4-carboxamide 
• 866846-58-4 5-methyl-N-phenyl-1-(p-tolyl)-1H-1,2,3-triazole-4-carboxamide 
• 94206-97-0 1-(4-chlorophenyl)-5-methyl-N-phenyl-1H-1,2,3-triazole-4-carboxamide 
• 866896-29-9 1-(4-methoxyphenyl)-5-methyl-N-phenyl-1H-1,2,3-triazole-4-carboxamide 
• 1384290-53-2 1-(2-hydroxyethyl)-5-methyl-N-phenyl-1H-1,2,3-triazole-4-carboxamide 
• 1384290-57-6 5-methyl-1-(methylamino)-N-phenyl-1H-1,2,3-triazole-4-carboxamide 

Relevant academic research and scientific papers

Copper-catalyzed chemoselective cross-coupling reaction of thioamides and α-diazocarbonyl compounds: Synthesis of enaminones

The development of operationally simple and cost-effective methods for C[sbnd]C bond formation reactions are highly important in pharmaceutical, agrochemical and material research. In this article we describe the first copper-catalyzed cross-coupling reaction of thioamides with acceptor/acceptor-substituted and acceptor-only substituted α-diazocarbonyl compounds to yield enaminones. The reaction shows broad substrate scope in terms of thioamides and diazocarbonyl compounds. Primary, secondary and tertiary thioamides all give enanminones when reacted with α-diazodiesters, α-diazoketoesters, α-diazodiketones, α-diazoketoamides, α-diazoesteramides, α-diazoketosulfones and α-diazomonoketones.

Intramolecular hydrogen bonding-assisted cyclocondensation of α-diazoketones with various amines: A strategy for highly efficient Wolff 1,2,3-triazole synthesis

A catalytic and highly efficient Wolff's cyclocondensation of α-diazoketones with aromatic and aliphatic amines has been realized for the first time by utilizing the strategy of an intramolecular hydrogen bonding-activating carbonyl group. This approach successfully solved the challenging problem of poor condensation efficiency in Wolff 1,2,3-triazole synthesis, and constitutes a powerful method for the synthesis of highly functionalized 1,2,3-triazoles. The Royal Society of Chemistry 2012.

REACTIONS OF α-SILYL-α-DIAZOKETONES WITH ARYLISOCYANATES AND ACYLISOTHIOCYANATES

(1-Diazo-2-oxoalkyl)silanes 1a,b react with arylisocyanates to give the 1-aryl-4-acyl-5-triisopropylsiloxy-1,2,3-triazoles 3.Hydrolytic or fluoride induced desilylation of these products affords the α-acyl-α-diazoacetamides 4.Diazoketone 1b reacts with ethoxycarbonyl and benzoyl isothiocyanate, but not with phenyl isothiocyanate, to produce 4-acyl-5-acylamino-1,2,3-thiadiazoles 5.

New 1-[quinolyl(4)]-1,2,3-triazoles: Synthesis and evaluation of antiinflammatory and analgesic properties. III

Several 1-[quinolyl(4)]-1,2,3-triazoles were synthesized by 1,3-dipolar cycloaddition of 4-azidoquinolines with activated methylene compounds. The synthesized compounds, tested for antiinflammatory and analgesic activities, resulted moderately active as antiinflammatories, but with a very interesting analgesic activity, sometimes higher than that of indomethacin, used as reference drug. Some of the triazole derivatives were evaluated also as antimicrobial, but none of them exhibited activity.