1421923-86-5 Usage
Uses
Used in Pharmaceutical Industry:
KPT-330, (E)-RN is used as an anticancer agent for its ability to block pancreatic cancer cell proliferation and reduce tumor growth in mice. Its selective inhibition of CRM1 makes it a potential candidate for the development of targeted cancer therapies.
Used in Cancer Research:
KPT-330, (E)-RN is used as a research tool for studying the role of CRM1 in cancer cell proliferation and tumor growth. Its selective inhibition of CRM1 can provide valuable insights into the molecular mechanisms underlying cancer development and progression, potentially leading to the discovery of novel therapeutic targets and strategies.
Check Digit Verification of cas no
The CAS Registry Mumber 1421923-86-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,2,1,9,2 and 3 respectively; the second part has 2 digits, 8 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1421923-86:
(9*1)+(8*4)+(7*2)+(6*1)+(5*9)+(4*2)+(3*3)+(2*8)+(1*6)=145
145 % 10 = 5
So 1421923-86-5 is a valid CAS Registry Number.
1421923-86-5Relevant academic research and scientific papers
HYDRAZIDE CONTAINING NUCLEAR TRANSPORT MODULATORS AND USES THEREOF
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, (2013/03/26)
The invention generally relates to nuclear transport modulators, e.g., CRM1 inhibitors, and more particularly to a compound represented by structural formula (I): or a pharmaceutically acceptable salt thereof, wherein the values and alternative values for the variables are as defined and described herein. The invention also includes the synthesis and use of a compound of structural formula I, or a pharmaceutically acceptable salt or composition thereof, e.g., in the treatment, modulation and/or prevention of physiological conditions associated with CRM1 activity.
