1422012-83-6Relevant academic research and scientific papers
Synthesis of α-alkylated β-ketoesters by alkoxycarbonylation/ Michael addition domino reaction
Wahl, Benoit,Philipson, Yann,Bonin, Hélène,Mortreux, André,Sauthier, Mathieu
, p. 1547 - 1552 (2013)
The palladium-catalyzed alkoxycarbonylation of an α-chloro ketone can be efficiently combined to a Michael addition reaction in a new two-step domino reaction, allowing the synthesis of original highly functionalized α-alkylated β-ketoesters. The scope of the reaction was extended to several α-chloro ketones and Michael acceptors with moderate to very good yields.
