Synthesis of α-alkylated β-ketoesters by alkoxycarbonylation/ Michael addition domino reaction

Article abstract of DOI:10.1021/jo3026143

The palladium-catalyzed alkoxycarbonylation of an α-chloro ketone can be efficiently combined to a Michael addition reaction in a new two-step domino reaction, allowing the synthesis of original highly functionalized α-alkylated β-ketoesters. The scope of the reaction was extended to several α-chloro ketones and Michael acceptors with moderate to very good yields.