1422012-87-0Relevant academic research and scientific papers
Primary β-amino acid salt-catalyzed asymmetric Michael addition of benzoylacetates to cyclic enones and its application for the synthesis of enantioenriched 1,5-diketones
Yoshida, Masanori,Kubara, Ami,Hara, Shoji
, p. 180 - 182 (2013/03/28)
The asymmetric Michael addition of benzoylacetates to cyclic enones was successfully carried out by using a primary β-amino acid salt catalyst. The reactions proceeded under mild reaction conditions to produce Michael adducts in high yields and with high enantioselectivities. The obtained Michael adducts were converted into β-benzoylmethylated cyclic ketones by decarboxylation without a significant loss of enantiomeric excess.
Synthesis of α-alkylated β-ketoesters by alkoxycarbonylation/ Michael addition domino reaction
Wahl, Benoit,Philipson, Yann,Bonin, Hélène,Mortreux, André,Sauthier, Mathieu
, p. 1547 - 1552 (2013/03/14)
The palladium-catalyzed alkoxycarbonylation of an α-chloro ketone can be efficiently combined to a Michael addition reaction in a new two-step domino reaction, allowing the synthesis of original highly functionalized α-alkylated β-ketoesters. The scope of the reaction was extended to several α-chloro ketones and Michael acceptors with moderate to very good yields.
