142230-57-7Relevant academic research and scientific papers
Palladium-catalyzed direct functionalization of imidazolinone: Synthesis of dibromophakellstatin
Lu, Jianming,Tan, Xianghui,Chen, Chuo
, p. 7768 - 7769 (2008/02/07)
The direct C-H functionalization of imidazolinone is achieved with Pd(OAc)2/NaOAc in DMSO. Dibromophakellstatin can be synthesized in five steps with 40% overall yield using this new C-H activation method. Copyright
Synthesis and anticonvulsant activity of some new 4-aryl-4-imidazoline-2-one derivatives
Calis,Dalkara,Ertan
, p. 592 - 594 (2007/10/02)
In this study, some new 4-aryl-4-imidazoline-2-one deriratives have been prepared by the reaction of potassium cyanate with some aminoethanone hydrochlorides. The structure of these compounds have been confirmed by UV, IR, 1H-NMR and elementary analysis. Their anticonvulsant activities were determined by maximal electroshock (MTS) and subcutaneous metrazol (scMet) tests according to the ADD (Antiepileptic Drug Development) programme Phase I. Neurotoxicity of the compounds was evaluated by rotarod test. While 2 of the compounds showed protection against ScMet induced seizures at 30 and 300 mg/kg dose levels, 3 of the compounds showed neurotoxicity.
