14225-75-3 Usage
Uses
Used in Pharmaceutical Industry:
5-CHLORO-2-(2-CHLORO-PHENYL)-1H-BENZOIMIDAZOLE is used as a chemical intermediate for the development of drugs targeting various medical conditions. Its unique structure allows it to be a promising candidate in the creation of novel therapeutic agents.
Used in Academic Research:
In academic research, 5-CHLORO-2-(2-CHLORO-PHENYL)-1H-BENZOIMIDAZOLE serves as a subject of study for understanding its chemical properties, reactivity, and potential interactions with biological systems, which can contribute to the advancement of scientific knowledge in chemistry and related fields.
Used in Chemical Synthesis:
5-CHLORO-2-(2-CHLORO-PHENYL)-1H-BENZOIMIDAZOLE is utilized as a building block in the synthesis of more complex organic compounds, taking advantage of its reactive sites for further chemical modifications and the creation of new molecules with specific properties and applications.
While the provided materials do not specify particular applications or industries beyond the general areas of pharmaceutical development, academic research, and chemical synthesis, further study and experimentation may uncover additional uses for 5-CHLORO-2-(2-CHLORO-PHENYL)-1H-BENZOIMIDAZOLE in various sectors.
Check Digit Verification of cas no
The CAS Registry Mumber 14225-75-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,4,2,2 and 5 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 14225-75:
(7*1)+(6*4)+(5*2)+(4*2)+(3*5)+(2*7)+(1*5)=83
83 % 10 = 3
So 14225-75-3 is a valid CAS Registry Number.
InChI:InChI=1/C13H8Cl2N2/c14-8-5-6-11-12(7-8)17-13(16-11)9-3-1-2-4-10(9)15/h1-7H,(H,16,17)
14225-75-3Relevant academic research and scientific papers
Sulfonic acid functionalized covalent organic frameworks as efficient catalyst for the one-pot tandem reactions
Gong, Kai,Li, Cunhao,Li, Haoran,Lu, Huilin,Wang, Yunyun,Zhang, Daquan,Zhang, Huimin
, (2022/02/02)
A covalent organic framework containing hydroxyl groups (HO-COF) has been predesigned and synthesized by the cyclotrimerization reaction of acetyls, which was used as a pre-established network to introduce propyl sulfonic acid through post-synthetic modification strategy, for the fabrication of SO3H-COF with graphene-like multilayer structure. SO3H-COF was employed as an effective heterogeneous catalyst for the synthesis of benzimidazoles, the synthesis of benzodiazepines and one-pot reductive amination of carbonyl compounds. The results indicated that the developed protocol has several advantages, such as high activity, broad substrate scope, short reaction time and excellent yields. The distinctive structures of SO3H-COF endowed the fantastic catalytic properties, good stability and circulation performance.
Copper catalyzed N-arylation of amidines with aryl boronic acids and one-pot synthesis of benzimidazoles by a Chan-Lam-Evans N-arylation and C-H activation/C-N bond forming process
Li, Jihui,Bénard, Sébastien,Neuville, Luc,Zhu, Jieping
supporting information, p. 5980 - 5983 (2013/02/23)
Mono-N-arylation of benzamidines 1 with aryl boronic acids 2 was effectively achieved in the presence of a catalytic amount of Cu(OAc) 2 and NaOPiv under mild aerobic conditions. Combining this step with an intramolecular direct C-H bond functionalization, catalyzed by the same catalytic system but under oxygen at 120 C, afforded benzimidazoles 3 in good to excellent yields.
