1422540-88-2 Usage
Uses
Used in Pharmaceutical Industry:
S-acetyl-PEG4-Propargyl is used as a molecular building block for the development of novel therapeutic agents. The expression is: S-acetyl-PEG4-Propargyl is used as a molecular building block for [application reason], which is to facilitate the creation of new drugs with improved water solubility and bioavailability.
Used in Drug Delivery Systems:
In the field of drug delivery, S-acetyl-PEG4-Propargyl is used as a PEG linker for [application reason], which is to enhance the stability, solubility, and bioavailability of drug molecules. The propargyl group's ability to form stable triazole linkages through Click Chemistry allows for the efficient conjugation of drugs to targeting moieties, improving drug targeting and reducing side effects.
Used in Bioconjugation:
S-acetyl-PEG4-Propargyl is used as a bioconjugation agent for [application reason], which is to enable the selective and stable attachment of biomolecules, such as proteins, peptides, or nucleic acids, to other molecules or surfaces. The sulfur acetyl group can be deprotected to produce a thiol compound, which can then be used for further conjugation reactions, while the propargyl group provides a handle for Click Chemistry-based conjugations.
Used in Materials Science:
In materials science, S-acetyl-PEG4-Propargyl is used as a functional polymer for [application reason], which is to improve the properties of various materials, such as hydrogels, nanoparticles, or surfaces, by enhancing their water solubility, biocompatibility, and responsiveness to external stimuli. The PEG linker and the reactive groups can be utilized to tailor the material's properties for specific applications, such as drug release, tissue engineering, or sensing.
Check Digit Verification of cas no
The CAS Registry Mumber 1422540-88-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,2,2,5,4 and 0 respectively; the second part has 2 digits, 8 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1422540-88:
(9*1)+(8*4)+(7*2)+(6*2)+(5*5)+(4*4)+(3*0)+(2*8)+(1*8)=132
132 % 10 = 2
So 1422540-88-2 is a valid CAS Registry Number.
1422540-88-2Relevant academic research and scientific papers
Efficient synthesis of diverse heterobifunctionalized clickable oligo(ethylene glycol) linkers: Potential applications in bioconjugation and targeted drug delivery
Goswami, Lalit N.,Houston, Zachary H.,Sarma, Saurav J.,Jalisatgi, Satish S.,Hawthorne, M. Frederick
, p. 1116 - 1126 (2013/03/28)
Herein we describe the sequential synthesis of a variety of azide-alkyne click chemistry-compatible heterobifunctional oligo(ethylene glycol) (OEG) linkers for bioconjugation chemistry applications. Synthesis of these bioorthogonal linkers was accomplished through desymmetrization of OEGs by conversion of one of the hydroxyl groups to either an alkyne or azido functionality. The remaining distal hydroxyl group on the OEGs was activated by either a 4-nitrophenyl carbonate or a mesylate (-OMs) group. The -OMs functional group served as a useful precursor to form a variety of heterobifunctionalized OEG linkers containing different highly reactive end groups, e.g., iodo, -NH2, -SH and maleimido, that were orthogonal to the alkyne or azido functional group. Also, the alkyne- and azide-terminated OEGs are useful for generating larger discrete poly(ethylene glycol) (PEG) linkers (e.g., PEG 16 and PEG24) by employing a Cu(i)-catalyzed 1,3-dipolar cycloaddition click reaction. The utility of these clickable heterobifunctional OEGs in bioconjugation chemistry was demonstrated by attachment of the integrin (αvβ3) receptor targeting peptide, cyclo-(Arg-Gly-Asp-d-Phe-Lys) (cRGfKD) and to the fluorescent probe sulfo-rhodamine B. The synthetic methodology presented herein is suitable for the large scale production of several novel heterobifunctionalized OEGs from readily available and inexpensive starting materials.
