142256-43-7

Upstream product

• 71-43-2 benzene 
• 142256-41-5 6-chloro-1-oxo-4-phenyl-1H-isochromene-3-carboxylic acid 
• 118-45-6 4-chlorophthalic anhydride 
• 33184-56-4 2-benzoyl-4-chlorobenzoic acid 

Downstream Products

• 1332697-21-8 diethyl 2-[(6-chloro-2-methyl-1-oxo-4-phenyl-1,2-dihydroisoquinolin-3-yl)methyl]propane-1,3-dioate 
• 1332697-20-7 3-(6-chloro-2-methyl-1-oxo-4-phenyl-1,2-dihydroisoquinolin-3-yl)propanoic acid 
• 1332697-19-4 tert-butyl [2-(6-chloro-2-methyl-1-oxo-4-phenyl-1,2-dihydroisoquinolin-3-yl)ethyl]carbamate 
• 1332696-99-7 3-(2-aminoethyl)-6-chloro-2-methyl-4-phenylisoquinolin-1(2H)-one hydrochloride 
• 142256-52-8 3-amino-6-chloro-2-methyl-4-phenylisoquinolin-1(2H)-one 
• 142256-14-2 t-Butyl N-(6-chloro-1,2-dihydro-2-methyl-4-phenyl-1-oxoisoquinolin-3-yl)carbamate 
• 142256-12-0 N-[6-Chloro-1,2-dihydro-2-methyl-4-phenyl-1-oxoisoquinolin-3-yl]-N'-(2,4-difluorophenyl)urea 
• 1026161-23-8 6-Chloro-2-methyl-1-oxo-4-phenyl-1,2-dihydro-isoquinoline-3-carbonyl chloride 

Relevant academic research and scientific papers

Identification of 3-aminomethyl-1,2-dihydro-4-phenyl-1-isoquinolones: A new class of potent, selective, and orally active non-peptide dipeptidyl peptidase IV inhibitors that form a unique interaction with Lys554

The design, synthesis, and structure-activity relationships of a new class of potent and orally active non-peptide dipeptidyl peptidase IV (DPP-4) inhibitors, 3-aminomethyl-1,2-dihydro-4-phenyl-1-isoquinolones, are described. We hypothesized that the 4-ph

Novel, Potent, and Orally Active Substance P Antagonists: Synthesis and Antagonist Activity of N-Benzylcarboxamide Derivatives of Pyridopyridine

A series of 4-phenylisoquinolone derivatives were synthesized and evaluated for NK1 (substance P) antagonist activity.Highly potent antagonists, 4-phenyl-3-isoquinolone-N-benzylcarboxamides (11), were discovered from the structure-activity relationship studies on the isoquinolone-urea lead 1a.Optimization of the activity in this series resulted in the development of 5-phenyl-6-pyridopyridine-N-benzylcarboxamides (30) which are highly potent orally active NK1 antagonists.Among the compounds synthesized, N--7,8-dihydro-N,7-dimethyl-8-oxo-5-(substituted phenyl)-6-pyridopyridinecarboxamides (30a,f,g) showed excellent antagonist activities with IC50 values (in vitro inhibition of 125I>BH-SP binding in human IM-9-cells) of 0.21-0.34 nM and ED50 values (in vivo inhibition of capsaicin-induced plasma extravasation in guinea-pig trachea, iv) of 0.017-0.030 mg/kg.These compounds exhibited significantly potent activity upon oral adiministration with ED50 values of 0.068-0.17 mg/kg.Conformational studies on 30g indicated that the two stable conformers of 30g are quite similar to those of CP-99,994.

Heterocyclic amine, derivatives, their production and use

A novel heterocyclic amine derivative of the general formula: STR1 wherein a ring A and a ring B stand independently for an optionally substituted benzene ring, Z° stands for O or S or STR2 stands for --CH2 --, X stands for O, S or NR1/su