142301-75-5Relevant articles and documents
Streamlined Synthesis of C(sp3)-Rich N-Heterospirocycles Enabled by Visible-Light-Mediated Photocatalysis
Flodén, Nils J.,Trowbridge, Aaron,Willcox, Darren,Walton, Scarlett M.,Kim, Yongjoon,Gaunt, Matthew J.
supporting information, p. 8426 - 8430 (2019/06/13)
We report a general visible-light-mediated strategy that enables the construction of complex C(sp3)-rich N-heterospirocycles from feedstock aliphatic ketones and aldehydes with a broad selection of alkene-containing secondary amines. Key to the
Synthesis of homopropargylamines from 2-cyanoazetidines
Quinodoz,Wright,Drouillat,David,Marrot,Couty
supporting information, p. 10072 - 10075 (2016/08/15)
2-Cyanoazetidines, easily accessible from β-amino alcohols, undergo ring-cleavage upon reaction with trimethylsilylazide and catalytic amounts of Bu2SnO, to give the corresponding homopropargylamines which are isolated as their N-Boc protected
Enantio- and diastereoselective palladium catalysed arylative and vinylative allene carbocyclisation cascades
Li, Meiling,Hawkins, Alison,Barber, David M.,Bultinck, Patrick,Herrebout, Wouter,Dixon, Darren J.
supporting information, p. 5265 - 5267 (2013/06/27)
The enantioselective synthesis of heavily decorated spirolactams has been accomplished via an arylative or vinylative allene carbocyclisation cascade. Mediated by silver phosphate, a range of allene-linked pro-nucleophiles and aryl or vinyl iodides were reacted in the presence of catalytic Pd(OAc)2 and chiral bis(oxazoline) ligands to afford the spirolactam products in good yields and high enantio- and diastereoselectivities. The Royal Society of Chemistry 2013.
