14231-47-1

Upstream product

• 63-91-2 L-phenylalanine 
• 701-99-5 Phenoxyacetyl chloride 
• 122-59-8 2-phenoxyacetic acid 

Downstream Products

• 192378-13-5 (S)-3-amino-N-phenoxyacetyl-4-phenylbutanone 
• 184916-15-2 N-((S)-1-Benzyl-3,3,3-trifluoro-2-hydroxy-propyl)-2-phenoxy-acetamide 
• 184916-14-1 N-((S)-1-Formyl-2-phenyl-ethyl)-2-phenoxy-acetamide 
• 184916-13-0 (S)-N-Methoxy-N-methyl-2-(2-phenoxy-acetylamino)-3-phenyl-propionamide 

Relevant academic research and scientific papers

Synthesis of metallo-β-lactamase inhibitors

α-Amido trifluoromethyl alcohols and ketones were synthesised via two independent routes using the Ruppert Reagent (TMS-CF3) and shown to be inhibitors of metallo-β-lactamases.

Trifluoromethyl alcohol and ketone inhibitors of metallo-β-lactamases

α-Amido trifluoromethyl alcohols and ketones were synthesised via two independent routes using Ruppert's Reagent (TMS-CF3) and shown to be the first reported synthetic inhibitors of metallo-β-lactamases.

Pharmaceutical composition having an excellent absorption property

A compound represented by the formula: STR1 wherein R1 is a hydrogen atom, a fluorine atom, a nitro group, a hydroxyl group or a hydroxyl group protected by an esterifying group; X is CO or SO2 ; --Y-- is a straight bond, a lower alkylene group, a substituted or unsubstituted vinylene group, or group having the formula --CH2 --O-- or --O--CH2 --; R2 is a substituted or unsubstituted phenyl or naphthyl group, or R2 --Y--CO is N-benzyloxycarbonylphenylalanyl, N-benzyloxycarbonyl-4-fluorophenylalanyl or N-(m-methoxycinnamoyl)-phenylalanyl group; or a non-toxic salt thereof is disclosed along with pharmaceutical compositions containing these compounds and methods of using these compositions to increase the rate of absorption of medicines.