1423120-72-2Relevant academic research and scientific papers
Palladium-catalyzed direct and regioselective C-5 desulfitative arylation of thiazolo[3,2- b ]-1,2,4-triazoles with sodium sulfinates
Wang, Shaohua,Liu, Wenjie,Lin, Juan,Jiang, Yi,Zhang, Qi,Zhong, Yue
supporting information, p. 586 - 590 (2014/03/21)
An efficient Pd(OAc)2-catalyzed direct arylation of thi?azolo[3,2-b]-1,2,4-triazoles with sodium sulfinates has been developed. The reaction shows high regioselectivity, good reaction efficiency and excellent functional group compatibility. This approach provides a useful protocol for the preparation of functionalized thiazolo[3,2-b]-1,2,4-triazole derivatives. Georg Thieme Verlag Stuttgart New York.
Highly regioselective ruthenium-catalyzed direct arylation of thiazolo[3,2-b]-1,2,4-triazoles with aryl iodides and aryl bromides via C-H bond activation
Zhang, Huiping
, p. 47 - 51 (2014/03/21)
We have developed a convenient ruthenium-catalyzed direct arylation for highly regioselective synthesis of thiazolo[3,2-b]-1,2,4-triazole derivatives via C-H bond activation. This transformation has provided a new synthetic route to a variety of thiazolo[3,2-b]-1,2,4-triazoles and afforded desired products in good yields.
First palladium-catalyzed direct regioselective C-5 (Het)arylation of mono- or disubstituted thiazolo[3,2-b][1,2,4]triazoles
Le Meur, Mikael,Bourg, Stephane,Massip, Stephane,Marchivie, Mathieu,Jarry, Christian,Guillaumet, Gerald,Routier, Sylvain
, p. 3704 - 3714 (2014/06/23)
An efficient and convenient method was developed for the formation of polysubstituted thiazolo[3,2-b][1,2,4]triazoles through C-5 (het)arylation. The direct C-H activation protocol giving access to di- and trisubstituted derivatives in excellent yields was optimized. The method is suitable for use with a wide range of (hetero)aryl bromides, and allows access to a collection of C-5,6 bis(het)aryl derivatives with full regioselectivity. The results are supported by a full description of all final compounds, and X-ray crystallographic data confirmed that the spectroscopic analyses were interpreted correctly. Copyright
Cu-catalyzed direct C-H bond functionalization: A regioselective protocol to 5-aryl thiazolo[3,2-b]-1,2,4-triazoles
Xie, Zengyang,Zhu, Xiaojun,Guan, Yangfan,Zhu, Dunru,Hu, Hongwen,Lin, Chen,Pan, Yi,Jiang, Juli,Wang, Leyong
supporting information, p. 1390 - 1398 (2013/05/08)
An efficient, regioselective C-5 arylation of thiazolo[3,2-b]-1,2,4- triazoles catalyzed by a simple copper catalyst was developed. This arylation proceeded smoothly and tolerated a variety of functional groups (44 examples). A wide range of functionalized thiazolo[3,2-b]-1,2,4-triazole derivatives were obtained in high yields (up to 99% yield). Possible catalytic cycles of the arylation were also discussed.
