1423120-75-5Relevant academic research and scientific papers
Cu-catalyzed direct C-H bond functionalization: A regioselective protocol to 5-aryl thiazolo[3,2-b]-1,2,4-triazoles
Xie, Zengyang,Zhu, Xiaojun,Guan, Yangfan,Zhu, Dunru,Hu, Hongwen,Lin, Chen,Pan, Yi,Jiang, Juli,Wang, Leyong
supporting information, p. 1390 - 1398 (2013/05/08)
An efficient, regioselective C-5 arylation of thiazolo[3,2-b]-1,2,4- triazoles catalyzed by a simple copper catalyst was developed. This arylation proceeded smoothly and tolerated a variety of functional groups (44 examples). A wide range of functionalized thiazolo[3,2-b]-1,2,4-triazole derivatives were obtained in high yields (up to 99% yield). Possible catalytic cycles of the arylation were also discussed.
