230301-82-3

Upstream product

• 142314-72-5 2-Bromomethyl-3-fluoro-benzoic acid methyl ester 
• 7677-24-9 trimethylsilyl cyanide 
• 699-90-1 3-fluoro-2-methylbenzoic acid 
• 230301-81-2 methyl 3-fluoro-2-methylbenzoate 

Downstream Products

• 230301-83-4 5-fluoro-3,4-dihydro-2H-isoquinolin-1-one 

Relevant academic research and scientific papers

SPIROCYCLIC TETRAHYDROQUINAZOLINES

Provided are compounds represented by Formula I, wherein R3, A, A1, A2, A3, E, E1, E2, L, Q, Z, and (aa) are as defined in the specification, and the pharmaceutically acceptable salts and solvates thereof. Compounds of Formula (I) are KRAS inhibitors and are thus useful to treat cancer and other diseases.

Spirocyclic tetrahydroquinazolines

The invention discloses spirocyclic tetrahydroquinazolines , and particularly provide compounds represented by Formula I shown in the specification, and pharmaceutically acceptable salts and solvates thereof. In the formula, R3, A, A1, A2, A3, E, E1, E2, L, Q, Z and a structure shown in the specification are as defined in the specification,. The compounds of formula I are KRAS inhibitors and are therefore useful in the treatment of cancer and other diseases.

Tetrahydrobenzindole derivatives

Compounds containing tetrahydrobenzindole which bind to serotonin receptor and are useful in treatment or prevention of disease induced by abnormality of central peripheral serotonin controlling functions.