1423159-86-7

Basic information

• Product Name: 2-(4-chlorobenzylidene)-N-[3-(pyridin-4-yl)-5-sulfanyl-4H-1,2,4-triazol-4-yl]hydrazine carbothioamide
• CAS NO: 1423159-86-7
• Molecular Weight: 389.892
• Mol File: 1423159-86-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(4-chlorobenzylidene)-N-[3-(pyridin-4-yl)-5-sulfanyl-4H-1,2,4-triazol-4-yl]hydrazine carbothioamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-chlorobenzylidene)-N-[3-(pyridin-4-yl)-5-sulfanyl-4H-1,2,4-triazol-4-yl]hydrazine carbothioamide(1423159-86-7)
• EPA Substance Registry System: 2-(4-chlorobenzylidene)-N-[3-(pyridin-4-yl)-5-sulfanyl-4H-1,2,4-triazol-4-yl]hydrazine carbothioamide(1423159-86-7)

Safety Data

• Hazardous Substances Data: 1423159-86-7(Hazardous Substances Data)

Upstream product

• 1570-45-2 isonicotinic acid ethylester 
• 1423159-81-2 4-(5-mercapto-3-(4'-pyridyl)-4H-1,2,4-triazol-4-yl)thiosemicarbazide 
• 104-88-1 4-chlorobenzaldehyde 
• 54-85-3 isoniazid 
• 61019-32-7 potassium 4-pyridinyldithiocarbazate 

Relevant articles and documents

Synthesis, anti-inflammatory activity, and QSAR study of some Schiff bases derived from 5-mercapto-3-(4′-pyridyl)-4H-1,2,4-triazol-4-yl- thiosemicarbazide

The purpose of this research is to synthesize better anti-inflammatory compounds derived from 5-mercapto-3-(4′-pyridyl)-4H-1,2,4-triazol-4-yl- thiosemicarbazide (5). 2-Substituted-N-[3-(pyridin-4-yl)-5-sulfanyl-4H-1,2,4- triazol-4-yl]hydrazine carbothioamide derivatives (6a-j)/(7a-e) are synthesized by the condensation of 5 with variously substituted aromatic aldehydes/1H-indole-2,3-diones, respectively, under conventional and microwave irradiation methods. The microwave method is found to be superior with higher chemical yields, tremendous reduction in time, and is environmentally benign as compared to conventional heating method. The chemical structures of the newly synthesized compounds (6/7) have been confirmed by IR, 1H NMR, and 13C NMR spectra and have been evaluated for anti-inflammatory activity by carrageenan-induced acute paw edema method in rats.