1423304-33-9

Basic information

• Product Name: 6-benzyl-2-(1-(trifluoromethyl)cyclopropyl)-5,6,7,8-tetrahydro-1,6-naphthyridine
• CAS NO: 1423304-33-9
• Molecular Weight: 332.368
• Mol File: 1423304-33-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 6-benzyl-2-(1-(trifluoromethyl)cyclopropyl)-5,6,7,8-tetrahydro-1,6-naphthyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 6-benzyl-2-(1-(trifluoromethyl)cyclopropyl)-5,6,7,8-tetrahydro-1,6-naphthyridine(1423304-33-9)
• EPA Substance Registry System: 6-benzyl-2-(1-(trifluoromethyl)cyclopropyl)-5,6,7,8-tetrahydro-1,6-naphthyridine(1423304-33-9)

Safety Data

• Hazardous Substances Data: 1423304-33-9(Hazardous Substances Data)

Upstream product

• 3612-20-2 1-phenylmethyl-4-piperidone 
• 1423304-22-6 (E)-3-ethoxy-1-(1-(trifluoromethyl)cyclopropyl)prop-2-en-1-one 
• 16675-58-4 1-Benzyl-4-(1-pyrrolidinyl)-1,2,3,6-tetrahydro-pyridine 
• 277756-46-4 1-(trifluoromethyl)cyclopropanecarboxylic acid 
• 1011460-56-2 1-trifluoromethyl-cyclopropanecarboxylic acid methoxy-methyl amide 

Relevant articles and documents

A concise one-pot synthesis of trifluoromethyl-containing 2,6-disubstituted 5,6,7,8-tetrahydroquinolines and 5,6,7,8-tetrahydronaphthyridines

5,6,7,8-Tetrahydroquinolines and 5,6,7,8-tetrahydronaphthyridines with appended trifluoromethyl groups are valuable chemotypes in medicinal chemistry due to the presence of a partially-saturated bicyclic ring and metabolically-stable CF3 group. 1H NMR studies were used to optimize the preparation of such compounds, using a three-step/one-pot procedure, to provide novel 2,6-disubstitued derivatives with a tertiary-substituent. Racemic 2,6-disubstituted tetrahydroquinolines were separated by chiral HPLC to provide single enantiomers.