142338-11-2

Upstream product

• 6873-44-5 p-chloro-N-methylbenzamide 
• 933-88-0 ortho-toluoyl chloride 
• 122-01-0 4-chloro-benzoyl chloride 
• 188674-85-3 2-(Bis-trimethylsilanyl-methyl)-N-methyl-benzamide 
• 145104-23-0 ortho-trimethylsilylmethyl-N-methylbenzamide 
• 2170-09-4 N,2-dimethylbenzamide 
• 188674-62-6 N-[2-(Bis-trimethylsilanyl-methyl)-benzoyl]-4-chloro-N-methyl-benzamide 

Relevant academic research and scientific papers

Catalytic Intramolecular Wittig Reaction Based on a Phosphine/Phosphine Oxide Catalytic Cycle for the Synthesis of Heterocycles

The catalytic intramolecular Wittig reactions of carbonyl-containing bromides are reported. The R3PO byproducts participate in the catalytic cycle; therefore, the Wittig reaction can be accomplished with only a catalytic amount of organophosphorus reagent. The reaction has also been applied to the efficient and selective synthesis of isoquinolin-1(2H)-ones, indoles, 2,3-dihydro-1H-2-benzazepin-1-ones, benzofurans, and 1,2-dihydroquinolines with a catalytic amount of phosphine oxide (0.1 equiv.) and a tetramethyldisiloxane/titanium isopropoxide [TMDS/Ti(OiPr)4] reductant system (yields: 35–88 %).

Fluoride ion-induced cyclization of o-[bis(trimethylsilyl)methyl]-N-acylbenzamide derivatives. New efficient synthesis of 2,3-differentially substituted 1(2H)-isoquinolones

A wide variety of 2-alkyl-3-alkyl, -3-aryl and -3-heteroaryl-1(2H)-isoquinolones have been obtained by fluoride ion-induced intramolecular alkenation of o-[bis(trimethylsilyl)methyl]-N-acylbenzamide derivatives.

A NEW SYNTHETIC ROUTE TO 2-METHYL-3-(ARYL OR ALKYL)-1-OXO-1,2-DIHYDROISOQUINOLINES via AN INTRAMOLECULAR WITTIG REACTION

2-Methyl-3-(aryl or alkyl)-1-oxo-1,2-dihydroisoquinolines 6a-g have been prepared via an intramolecular Wittig olefination reaction from the N-acyl-N-methyl-o-triphenylphosphoniobenzamide bromides 5a-g.