142350-59-2

Upstream product

• 134816-21-0 (5S)-1-((2S)-2-hydroxy-isovaleryl)-2-oxo-4-methoxy-5-benzyl-3-pyrroline 
• 142350-62-7 (S)-1-[(S)-1-((S)-2-{[(S)-2-((S)-2-Benzyloxycarbonylamino-3-methyl-butyrylamino)-3-methyl-butyryl]-methyl-amino}-3-methyl-butyryl)-pyrrolidine-2-carbonyl]-pyrrolidine-2-carboxylic acid 
• 17407-55-5 (S)-2-Hydroxy-3-methylbutanoic acid 
• 42417-65-2 Z-MeVal-OH 
• 962-39-0 L-Phenylalanine benzyl ester 
• 1148-11-4 N-Benzyloxycarbonyl-L-proline 
• 142370-94-3 tert-butyl -L-valyl-(N-methyl-L-valyl)-L-prolyl-L-prolinate 
• 142350-64-9 Val-MeVal-Pro-ProOtBu*HCl 
• 142350-58-1 tert-butyl -(N-methyl-L-valyl)-L-prolyl-L-prolinate 
• 142350-63-8 H-MeVal-Pro-ProOtBu * HCl 
• 142350-57-0 tert-butyl -L-prolyl-L-prolinate 
• 182573-16-6 (S)-N-[(S)-1-Benzyl-2-(2,2-dimethyl-4,6-dioxo-[1,3]dioxan-5-ylidene)-2-hydroxy-ethyl]-2-(tert-butyl-dimethyl-silanyloxy)-3-methyl-butyramide 
• 51871-50-2 (S)-benzyl 2-((S)-2-(tert-butoxycarbonyl)pyrrolidine-1-carbonyl)pyrrolidine-1-carboxylate 
• 142350-55-8 benzyl N-<(2S)-2-hydroxy-isovaleryl>-L-phenylalaninate 

Downstream Products

• 123884-00-4 dolastatin 15 

Relevant academic research and scientific papers

Total Synthesis of the Proposed Structure of Dolastatin 15

Efficient synthesis of dolastatin 15 (1) was accomplished following a convergent strategy.The pyrrolidinone cycle of 5 was obtained by thermic cyclization of the corresponding Meldrum's adduct 4.The methylation of the enol function was performed under Mit