51871-50-2

Upstream product

• 1148-11-4 N-Benzyloxycarbonyl-L-proline 
• 2812-46-6 proline tert-butyl ester 

Downstream Products

• 142350-59-2 (5S)-1-<(2S)-O-<-L-valyl-(N-methyl-L-valyl)-L-prolyl-L-prolyl>-2-hydroxy-isovaleryl>-2-oxo-4-methoxy-5-benzyl-3-pyrroline 
• 123884-00-4 dolastatin 15 
• 142370-94-3 tert-butyl -L-valyl-(N-methyl-L-valyl)-L-prolyl-L-prolinate 
• 142350-62-7 (S)-1-[(S)-1-((S)-2-{[(S)-2-((S)-2-Benzyloxycarbonylamino-3-methyl-butyrylamino)-3-methyl-butyryl]-methyl-amino}-3-methyl-butyryl)-pyrrolidine-2-carbonyl]-pyrrolidine-2-carboxylic acid 
• 142350-58-1 tert-butyl -(N-methyl-L-valyl)-L-prolyl-L-prolinate 

Relevant academic research and scientific papers

Amides in one pot from Carboxylic Acids and Amines via Sulfinylamides

An efficient method has been developed for the direct amidification of carboxylic acids via sulfinylamides preformed in situ by the reaction of pure amines with prop-2- ene-1-sulfinyl chloride. The method can be applied to aliphatic acids, including pivalic acid, aromatic acids, and primary and secondary amines. It is compatible with acids bearing unprotected alcohol, phenol, and ketone moieties and applicable to the synthesis of peptides. It does not induce their a-epimerization.

Total Synthesis of the Proposed Structure of Dolastatin 15

Efficient synthesis of dolastatin 15 (1) was accomplished following a convergent strategy.The pyrrolidinone cycle of 5 was obtained by thermic cyclization of the corresponding Meldrum's adduct 4.The methylation of the enol function was performed under Mit