1423778-39-5

Basic information

• Product Name: 5-bromo-2-(phenylethynyl)quinoline
• Synonyms: 5-bromo-2-(phenylethynyl)quinoline
• CAS NO: 1423778-39-5
• Molecular Weight: 308.177
• Mol File: 1423778-39-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 5-bromo-2-(phenylethynyl)quinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 5-bromo-2-(phenylethynyl)quinoline(1423778-39-5)
• EPA Substance Registry System: 5-bromo-2-(phenylethynyl)quinoline(1423778-39-5)

Safety Data

• Hazardous Substances Data: 1423778-39-5(Hazardous Substances Data)

Upstream product

• 536-74-3 phenylacetylene 
• 99455-13-7 5-bromo-2-chloroquinoline 
• 846038-45-7 5-bromoquinoline N-oxide 
• 4964-71-0 5-bromoquinoline 
• 611-34-7 5-Aminoquinoline 

Relevant articles and documents

Potassium Hydroxide-Catalyzed Alkynylation of Heteroaromatic N-Oxides with Terminal Alkynes

An efficient potassium hydroxide-catalyzed alkynylation of heteroaromatic N-oxides under transition-metal-free conditions with the assistance of visible-light has been developed. Various C2-alkynylheterocycles were obtained in up to 92% yield with good functional group tolerance. This new method is operational simple, highly efficient, atom economic, and environmental friendly. (Figure presented.).

Synthesis and biological evaluation of 2-(arylethynyl)quinoline derivatives as mGluR5 antagonists for the treatment of neuropathic pain

We described here the synthesis and biological evaluation of mGluR5 antagonists containing a quinoline ring structure. Using intracellular calcium mobilization assay (FDSS assay), we identified compound 5n, showing high inhibitory activity against mGluR5. In addition, it was found that compound 5n has excellent stability profile. Finally, this compound exhibited favorable analgesic effects in spinal nerve ligation model of neuropathic pain, which is comparable to gabapentin.