99455-13-7

Basic information

• Product Name: 5-BROMO-2-CHLOROQUINOLINE
• Synonyms: 5-BROMO-2-CHLOROQUINOLINE;2-Chloro-5-BroMoquinoline;5-Bromo-2-chloro-1-azanaphthalene
• CAS NO: 99455-13-7
• Molecular Formula: C₉H₅BrClN
• Molecular Weight: 242.5
• Mol File: 99455-13-7.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 325.741 °C at 760 mmHg
• Flash Point: 150.803 °C
• Appearance: /
• Density: 1.673 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.68
• CAS DataBase Reference: 5-BROMO-2-CHLOROQUINOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-BROMO-2-CHLOROQUINOLINE(99455-13-7)
• EPA Substance Registry System: 5-BROMO-2-CHLOROQUINOLINE(99455-13-7)

Safety Data

• Statements: 41
• Safety Statements: 26-39
• Hazardous Substances Data: 99455-13-7(Hazardous Substances Data)

Usage

General Description

5-Bromo-2-chloroquinoline is a chemical compound with the molecular formula C9H5BrClN. It is a heterocyclic aromatic compound that contains a quinoline ring with bromine and chlorine substituents. 5-Bromo-2-chloroquinoline is used in the synthesis of pharmaceuticals and agrochemicals. It has also been investigated for its potential use as a ligand in coordination chemistry. 5-Bromo-2-chloroquinoline exhibits a range of chemical and physical properties that make it useful in various industrial and research applications, including its ability to act as a catalyst and its potential as a building block in the synthesis of complex organic molecules.

InChI:InChI=1/C9H5BrClN/c10-7-2-1-3-8-6(7)4-5-9(11)12-8/h1-5H

Upstream product

• 917341-34-5 (2E)-N-(3-bromophenyl)-3-phenylprop-2-enamide 
• 99465-09-5 5-bromohydroxyquinoline 
• 99465-09-5 5-bromoquinolin-2(1H)-one 
• 99465-10-8 7-bromo-1,2-dihydroquinolin-2-one 
• 612-62-4 2-Chloroquinoline 
• 128-08-5 N-Bromosuccinimide 
• 7732-18-5 water 
• 4964-71-0 5-bromoquinoline 
• 611-34-7 5-Aminoquinoline 
• 99465-18-6 (E)-N-(3-bromophenyl)-3-ethoxypropenamide 
• 846038-45-7 5-bromoquinoline N-oxide 
• 591-19-5 m-Bromoaniline 

Downstream Products

• 99455-06-8 5-bromo-2-methoxyquinoline 
• 1016315-03-9 (5-Bromo-quinolin-2-yl)-(2-methoxy-benzyl)-amine 
• 347146-12-7 5-bromoquinolin-2-amine 
• 1423778-39-5 5-bromo-2-(phenylethynyl)quinoline 
• 1632293-77-6 C₃₂H₁₄BBrF₁₅N 

Relevant articles and documents

IMIDAZOPIPERAZINONE INHIBITORS OF TRANSCRIPTION ACTIVATING PROTEINS

The present disclosure relates to heterocyclic compounds and methods which may be useful as inhibitors of transcription activating proteins such as CBP and P300 for the treatment or prevention of diseases such as proliferative diseases, inflammatory disorders, autoimmune diseases, and fibrotic diseases.

Reversible frustrated lewis pair addition of n-heterocycles to unsaturated c-c bonds

N-Heterocycle-tethered olefins and alkynes are cyclized by addition of the N-heterocycle and B(C6F5)3 across the unsaturation. This activation is demonstrated to be reversible at high temperatures. Georg Thieme Verlag Stuttgart New York.

Synthesis and biological evaluation of 2-(arylethynyl)quinoline derivatives as mGluR5 antagonists for the treatment of neuropathic pain

We described here the synthesis and biological evaluation of mGluR5 antagonists containing a quinoline ring structure. Using intracellular calcium mobilization assay (FDSS assay), we identified compound 5n, showing high inhibitory activity against mGluR5. In addition, it was found that compound 5n has excellent stability profile. Finally, this compound exhibited favorable analgesic effects in spinal nerve ligation model of neuropathic pain, which is comparable to gabapentin.