1423914-98-0Relevant academic research and scientific papers
Efficient synthesis of ESI-09, a novel non-cyclic nucleotide EPAC antagonist
Chen, Haijun,Ding, Chunyong,Wild, Christopher,Liu, Huiling,Wang, Tianzhi,White, Mark A.,Cheng, Xiaodong,Zhou, Jia
, p. 1546 - 1549 (2013)
A concise and efficient synthetic approach to producing a novel non-cyclic nucleotide EPAC antagonist ESI-09 and its new analogs is reported. Key features of the synthesis include a mild and reliable one-pot procedure for an isoxazole synthon, as well as a modified one-pot protocol for the cyanomethyl ketone key intermediate. The synthesis requires inexpensive starting materials and only three linear steps for the completion in a total yield of 53%.
