1424-50-6Relevant academic research and scientific papers
CYCLOALKYLNITRILE PYRAZOLE CARBOXAMIDES AS JANUS KINASE INHIBITORS
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Page/Page column 116-117, (2013/04/10)
Cycloalkylnitrile pyrazole carboxamides as JAK inhibitors useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer are provided.
Reactivity of arenesulfinic acids as nucleophiles in the addition reaction to 2-haloacrylonitriles
Zvezdova,Stoeva,Aleksiev
, p. 447 - 452 (2008/02/11)
The nucleophilic addition reactions of both the non-substituted and p-substituted benzenesulfinic acids with 2-chloro- and 2-bromoacrylonitriles have been studied. The structures of the 3-benzenesulfonyl-2- halogenopropanenitriles thus obtained were confi
The Diels-Alder reactivity of (E)-3-phenylsulfonylprop-2-enenitrile, a cyanoacetylene equivalent
Bradley, Pamela J.,Grayson, David H.
, p. 1794 - 1799 (2007/10/03)
(E)-3-Phenylsulfonylprop-2-enenitrile undergoes facile Diels-Alder reactions, moderate regioselectivity being observed with several unsymmetrical dienes. Danishefsky's diene and furfuryl alcohol react regioselectively. The cycloadducts formed with cyclopentadiene and with anthracene undergo base-catalysed elimination of benzenesulfinic acid to yield α,β-unsaturated nitriles.
