64326-47-2

Basic information

• Product Name: (E)-3-(phenylsulfonyl)acrylonitrile
• Synonyms: (E)-3-(phenylsulfonyl)acrylonitrile
• CAS NO: 64326-47-2
• Molecular Formula: C₉H₇NO₂S
• Molecular Weight: 193
• Mol File: 64326-47-2.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (E)-3-(phenylsulfonyl)acrylonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-3-(phenylsulfonyl)acrylonitrile(64326-47-2)
• EPA Substance Registry System: (E)-3-(phenylsulfonyl)acrylonitrile(64326-47-2)

Safety Data

• Hazardous Substances Data: 64326-47-2(Hazardous Substances Data)

Usage

General Description

(E)-3-(phenylsulfonyl)acrylonitrile is a chemical compound with the molecular formula C10H7NO2S. It is a nitrile compound that contains a phenylsulfonyl group, which is a sulfonyl group attached to a phenyl ring. This chemical is known to be a versatile building block in organic synthesis, and it is used in the production of various pharmaceuticals and agrochemicals. It is also used as a precursor in the synthesis of various organic compounds, including carbon-carbon and carbon-nitrogen bond-forming reactions. Additionally, (E)-3-(phenylsulfonyl)acrylonitrile is also used in the production of dyes, pigments, and other fine chemicals. Its versatile reactivity and applications make it a valuable compound in various industries.

Upstream product

• 1424-49-3 chloro-2 thiophenyl-3 propionitrile 
• 873-55-2 sodium benzenesulfonate 
• 920-37-6 2-Chloroacrylonitrile 
• 7205-98-3 chloromethyl phenyl sulfone 
• 107-14-2 chloroacetonitrile 
• 1424-50-6 2-chloro-3-(phenylsulfonyl)propanenitrile 
• 107-13-1 acrylonitrile 
• 1950-77-2 benzenesulfonyl iodide 
• 4554-16-9 2,3-dibromopropionitrile 

Downstream Products

• 57597-62-3 3,3-dimethoxypropionitrile 
• 711-29-5 3-phenylsulfonyl-2(Z)-propenoic acid 
• 104-85-8 para-methylbenzonitrile 
• 620-22-4 3-Methylbenzonitrile 

Relevant articles and documents

Photoredox Alkenylation of Carboxylic Acids and Peptides: Synthesis of Covalent Enzyme Inhibitors

The synthesis of vinyl sulfones and (α,β-unsaturated) nitriles from carboxylic acids was realized through oxidative decarboxylation with 1,4-dicyanoanthracene as an organic photoredox catalyst. Various types of C-radicals are generated and used to construct three different classes of potential covalent protease inhibitors. The procedure is functional group tolerant and applicable to natural products and druglike scaffolds. It may serve for the rapid construction of screening candidates as demonstrated by a three-step synthesis of the known protease inhibitor K11777.

Facile method for solid-phase synthesis of vinyl sulfones using polystyrene-supported selenomethyl aryl sulfone

Treatment of novel polystyrene-supported selenomethyl aryl sulfone with LDA followed by alkylation and oxidation elimination efficiently afforded vinyl sulfones in good yields and purities.

Polystyrene-supported selenosulfonates: Efficient reagents for regio- and stereocontrolled synthesis of vinyl sulfones

Two novel polystyrene-supported selenosulfonates reagents have been developed. As reagents for boron trifluoride catalyzed or AIBN catalyzed addition to olefins were successfully demonstrated and have been used for regioselective synthesis of vinyl sulfon