1424328-35-7Relevant academic research and scientific papers
Orthanilic acid-promoted reverse turn formation in peptides
Kale, Sangram S.,Priya, Gowri,Kotmale, Amol S.,Gawade, Rupesh L.,Puranik, Vedavati G.,Rajamohanan,Sanjayan, Gangadhar J.
, p. 2222 - 2224 (2013)
Orthanilic acid (2-aminobenzenesulfonic acid, SAnt), an aromatic β-amino acid, has been shown to be highly useful in inducing a folded conformation in peptides. When incorporated into peptide sequences (Xaa- SAnt-Yaa), this rigid aromatic β-amino acid strongly imparts a reverse-turn conformation to the peptide backbone, featuring robust 11-membered-ring hydrogen-bonding.
