14248-71-6

Basic information

• Product Name: 2-ETHOXYNICOTINONITRILE 98%3-CYANO-2-ETHOXYPYRIDINE
• Synonyms: 2-ETHOXYNICOTINONITRILE 98%3-CYANO-2-ETHOXYPYRIDINE;2-Ethoxynicotinonitrile 98%;Albb-004988;3-Pyridinecarbonitrile, 2-ethoxy-;2-ethoxy-3-Pyridinecarbonitrile;2-Ethoxynicotinonitrile98%
• CAS NO: 14248-71-6
• Molecular Formula: C8H8N2O
• Molecular Weight: 148.16192
• Product Categories: blocks;Carboxes;Pyridines
• Mol File: 14248-71-6.mol
• Article Data: 7

Chemical Properties

• Melting Point: 36-38
• Boiling Point: 256 °C at 760 mmHg
• Flash Point: 108.6 °C
• Appearance: /
• Density: 1.12 g/cm³
• Vapor Pressure: 0.0158mmHg at 25°C
• Refractive Index: 1.52
• Storage Temp.: Keep Cold
• CAS DataBase Reference: 2-ETHOXYNICOTINONITRILE 98%3-CYANO-2-ETHOXYPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-ETHOXYNICOTINONITRILE 98%3-CYANO-2-ETHOXYPYRIDINE(14248-71-6)
• EPA Substance Registry System: 2-ETHOXYNICOTINONITRILE 98%3-CYANO-2-ETHOXYPYRIDINE(14248-71-6)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 14248-71-6(Hazardous Substances Data)

Usage

General Description

2-Ethoxynicotinonitrile, also known as 3-Cyano-2-ethoxypyridine, is a complex chemical compound. It primarily belongs to the pyridine and pyrimidine chemical class, consisting of a blend of heterocyclic aromatic organic compounds. These types of chemical compounds are known for their extensive applications, including in the pharmaceutical industry, agrochemical production, and food industry. The '98%' listed with the chemical name suggests this compound is available with a purity level of 98%, making it suitable for conducting high-level research or for manufacturing purpose where a high degree of purity is required. Although there isn't specific information on the properties of 2-Ethoxynicotinonitrile, chemicals like this generally need to be handled with care under standard safety protocols due to their reactive nature.

InChI:InChI=1/C8H8N2O/c1-2-11-8-7(6-9)4-3-5-10-8/h3-5H,2H2,1H3

Upstream product

• 20577-27-9 2-hydroxy-3-cyanopyridine 
• 64-17-5 ethanol 
• 52200-48-3 3-bromo-2-chloropyridine 
• 557-21-1 zinc(II) cyanide 
• 57883-25-7 3-bromo-2-ethoxypyridine 
• 6602-54-6 2-chloro-3-pyridinecarbonitrile 

Downstream Products

• 851773-43-8 (2-ethoxypyridin-3-yl)methanamine 

Relevant articles and documents

Discovery of the Bruton's Tyrosine Kinase Inhibitor Clinical Candidate TAK-020 (S)-5-(1-((1-Acryloylpyrrolidin-3-yl)oxy)isoquinolin-3-yl)-2,4-dihydro-3 H-1,2,4-triazol-3-one, by Fragment-Based Drug Design

This publication details the successful use of FBDD (fragment-based drug discovery) principles in the invention of a novel covalent Bruton's tyrosine kinase inhibitor, which ultimately became the Takeda Pharmaceuticals clinical candidate TAK-020. Describe

COMBINATION TREATMENTS COMPRISING ADMINISTRATION OF 1H-PYRAZOLO[4,3-B]PYRIDINES

The present invention provides 1H-pyrazolo[4,3-b]pyridin-7-amines of formula (I) as PDE1 inhibitors together with a second compound useful in the treatment of a neurodegenerative disorder and their combined use as a medicament, in particular for the treatment of neurodegenerative and/or cognitive disorders.

COMBINATION TREATMENTS COMPRISING ADMINISTRATION OF 1H-PYRAZOLO[4,3-B]PYRIDINES

The present invention provides 1H-pyrazolo[4,3-b]pyridin-7-amines of formula (I) as PDE1 inhibitors together with a second compound which compound is useful in the treatment of a psychiatric disorder and their combined use as a medicament, in particular for the treatment of psychiatric and/or cognitive disorders.